Cognitive Training, Depression, Anxiety, Emotion Regulation, Emotion Training
Conditions
Brief summary
The research proposes to use an innovative solution to shape brain circuits that support executive function and emotion reactivity -using targeted neurobehavioral intervention.
Detailed description
Participants will be recruited locally in the San Francisco Bay area with certain symptoms of anxiety and depression. They will complete a clinical assessment and then take part in a cognitive-emotion training delivered online.
Interventions
Participants will complete the intervention by logging into a secure online website and complete computerized neurobehavioral tasks. Tasks will train the following - cognitive control, working memory and task shifting with two different tasks that engage these skills and positivity biases.
Sponsors
Stanford University
Study design
Allocation
RANDOMIZED
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
ALL
Age
18 Years to 60 Years
Healthy volunteers
No
Inclusion criteria
* Diagnosis of depression on the SCID, a total Ham-D≥16 and Ham-D anxiety/somatization subscale ≥ 7.
Exclusion criteria
* Current medication for psychiatric disorders * Pregnant females * Head trauma or injury that resulted in loss of consciousness * MRI contraindication
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Completion | 60 days | We anticipate that participants will complete at least 30-days of the intervention. |
| Proximal outcomes | 60 days | We anticipate that proximal measures of symptoms will show improvement following the training in terms of emotional reactivity, implicit emotion regulation, negative emotional memory bias, attentional bias for threat, executive functions behaviorally and N-back during fMRI as well as resting-state fMRI connectivity. |
| Distal outcomes | 5 months | We anticipate that anxiety and depression symptoms, explicit emotion regulation capacities and quality of life reported on self-report measures will show improvement. |
Countries
United States
Outcome results
None listed