Effect of Acute Treatment With N2O on Inhibitory Pain Mechanisms in Healthy Subject

Status

UNKNOWN

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01616004

Acronym

N2O

Enrollment

Registered

2012-06-11

Start date

2014-10-31

Completion date

2016-08-31

Last updated

2014-09-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Pain

Brief summary

The purpose of this study is to determine whether N2O (laughing gas) has an antinociceptive effects in healthy volunteers.

Detailed description

10 healthy volunteers will come twice to the pain medicine unit, at 1 visit they'll get N2O and in the second visit they'll get air as placebo, they won't know what they're getting. During the visit they'll get heat stimulus using QST and will have to report their pain using eVAS (scale from 0 to 100 when 0 is no pain and 100 is the worst pain imagine).

Interventions

DRUGN2O

DRUGAir

sham comparator

Study design

Allocation

NON_RANDOMIZED

Intervention model

CROSSOVER

Primary purpose

BASIC_SCIENCE

Masking

SINGLE (Subject)

Eligibility

Sex/Gender

ALL

Age

18 Years to 50 Years

Healthy volunteers

Yes

Inclusion criteria

* 18-50 years old * women and men * healthy

Exclusion criteria

* smokers * medication use pregnant woman cardiovascular disease

Design outcomes

Primary

Measure	Time frame
Pain Scores on the Visual Analog Scale	August 2016

Countries

Israel

Contacts

Primary ContactSilviu Brill, M.D

silviub@tasmc.health.gov.il972-3-6974477

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026