Polycystic Ovary Syndrome
Conditions
Keywords
polycystic Ovary syndrome (PCOS), diet, mediterranean diet, high protein diet
Brief summary
Polycystic ovary syndrome (PCOS) affects 5-10% of women and is the most common endocrine syndrome.PCOS is associated with infertility, risk for obesity and type 2 diabetes. The elevated insulin characteristic of PCOS is likely to play a major role in its symptoms. restricted calorie High protein diet and mediterranean diet may improve insulin sensitivity and therefore lower androgen production in women with pcos women.the purpose of this study is to determine which diet is more effective in improving metabolic and reproductive outcomes.
Detailed description
Polycystic ovary syndrome (PCOS) is a heterogeneous syndrome affecting 5-10% of women of reproductive age. It is characterized by elevated circulating insulin, reduced insulin sensitivity, infertility, hyperandrogenism, and a multitude of symptoms that result in a decreased quality of life. The elevated insulin characteristic of PCOS is likely to play a major role in its pathogenesis by reducing insulin sensitivity and stimulating excess androgen production hence causing an hormonal imbalance. Low calories diets have shown to improve pcos symptoms but the optimal diet for all pcos women is still unknown. In this study, our purpose is to compare two lowering insulin restricted calories diets in order to find the optimal diet for improving metabolic and endocrin outcomes in pcos women we will also investigate which diet has the best long lasting compliance.
Interventions
1500 k/cal 30% fat
50 pcos diagnosed women will be assigned to high protein diet for 18 month
Sponsors
Study design
Eligibility
Inclusion criteria
* Polycystic ovary syndrome
Exclusion criteria
* Pregnancy * Lactation 6 month prior to study * Known hyperandrogenism * More then 5 kg weight loss 6 month prior to study * Imbalance pituitary hormones * Alcohol or drug abuse * Chronic disease - kidney/heart/diabetes/lung * Psychiatric disease * Drug use accept contraceptive pills
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| improvement in metabolic outcomes of women with pcos | 18 months |
Secondary
| Measure | Time frame |
|---|---|
| improvement in clinical symptoms: acne, hirsutism and menstrual regularity | 18 months |
Countries
Israel