Neuromuscular Electrical Stimulation (NMES) and Muscle Protein Accretion (ES-PRO)

The Effect of Neuromuscular Electrical Stimulation on Post-prandial Muscle Protein Accretion in Healthy Elderly Men

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01615276

Acronym

ES-PRO

Enrollment

Registered

2012-06-08

Start date

2012-10-31

Completion date

2013-01-31

Last updated

2013-05-31

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Sarcopenia

Keywords

Neuromuscular Electrical Stimulation, Ageing, Protein ingestion

Brief summary

In the present study, the effect of a bolus of intrinsically labeled milk directly after one-legged NMES will be studied.

Interventions

DEVICEEnraf Nonius Tensmed S84 for Neuromuscular electrical stimulation (NMES)

One our of one-legged neuromuscular electrical stimulation (NMES)

DEVICENo Enraf Nonius Tensmed S84 for Neuromuscular electrical stimulation (NMES) NMES

No neuromuscular electrical stimulation (NMES) will be applied in the control leg

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

BASIC_SCIENCE

Masking

NONE

Eligibility

Sex/Gender

MALE

Age

65 Years to 85 Years

Healthy volunteers

Yes

Inclusion criteria

* Male * Age 65 - 85 years * 18.5 \< BMI \< 30 kg∙m2

Exclusion criteria

* Type II diabetes * All co morbidities interacting with mobility and muscle metabolism of the lower limbs (e.g. arthrosis, arthritis, spasticity/rigidity, all neurological disorders, paralysis, hip/knee surgery). * Use of anticoagulants, blood diseases, allergy for lidocaine * Use of NSAIDs and acetylsalicylic acid * Patients suffering from PKU (Phenylketonuria) * Presence of implantable cardioverter defibrillator and/or pacemaker * Performed regular resistance type exercise in the past 6 months

Design outcomes

Primary

Measure	Time frame
Tracer enrichment in the muscle biopsy	4 hours after protein ingestion

Secondary

Measure	Time frame
Fractional synthetic rate (FSR)	0-4 hours after protein ingestion

Countries

Netherlands

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 26, 2026