Missed Abortion
Conditions
Keywords
missed abortion, miscarriage
Brief summary
Missed abortion is a condition where the fetus has perished but the miscarriage is not expelled. Women often present at a routine ultrasound or with a slight brownish discharge. Traditionally this condition has been treated with curettage or vacuum aspiration. Lately, medical treatment has become more common due to less risk of infection and other complications. The routine medical treatment is 800mcg of misoprostol administered vaginally. We wish to examine of repeated doses of 400mcg misoprostol after the initial 800mcg vaginal misoprostol increases efficacy of the treatment.
Interventions
DRUGmisoprostol
repeated doses of misoprostol. 400mcg of oral misoprostol given at 3, 5, 7 and 9 hours.
Sponsors
Kristina Gemzell Danielsson
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 55 Years
Healthy volunteers
No
Inclusion criteria
* over 18 years of age healthy no contraindication to medical treatment visible fetal structures such as yolk sac or fetus
Exclusion criteria
* empty gestational sac more than sparse bleeding or dilated cervix mental instability after diagnosis contraindication to medical treatment
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Efficacy | 1 day | Complete abortion as judged by ultrasound |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Acceptability | 1 day, 1 week, 2 weeks, 3 weeks, 5 weeks | questionnaire on future choice of treatment method. Surgical or medical treatment if free choice. If having to have medical would she choose repeated doses or single dose? |
Countries
Sweden
Outcome results
None listed