Comparison of Breathing Pattern During Neurally Adjusted Ventilatory Assist Ventilation and Pressure Support Ventilation

Comparison of Breathing Pattern During PSV and NAVA

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01614873

Enrollment

Registered

2012-06-08

Start date

2012-05-31

Completion date

2012-08-31

Last updated

2013-04-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Respiratory System Abnormalities

Keywords

Breathing Pattern, Mechanical Ventilation, Pressure support ventilation, Neurally Adjusted Ventilatory Assist

Brief summary

Comparison of Breathing pattern during mechanical ventilation. Two modes of mechanical ventilation are compared (Pressure Support Ventilation and Neurally Adjusted Ventilatory Assist)

Detailed description

Eligibility : healthy subject without respiratory complications in the past Subjects will breath spontaneously without mechanical ventilation, with Pressure Support Ventilation and with Neurally Adjusted Ventilatory Assist during. Three levels of pressurisation will be tested : 5 cmH2O, 8 cmH2O and 12 cmH2O Duration of each condition will be about 15 minutes. Measurements will include:Flow, airway pressure, SaO2, PtCO2, diaphragmatic electromyography, chest wall motion by optoelectronic plethysmography

Interventions

DEVICEServo-i® ventilator, MAQUET,Critical Care, Sweden

Electrical activity of the diaphragm will be obtained through a naso-gastric tube with multiple array of electrodes placed at its distal end (Eadi catheter® , Maquet Critical Care, Sweden). Subject will be ventilated with a mouthpiece interface. NAVA will be compared to Pressure Support using the same ventilator. Once the pattern of breathing will be stabilized (10 minutes) in each condition (see arm) the following parameters will be recorded during 5 minutes and compared : tidal volume, inspiratory time, expiratory time, transcutaneous CO2 pressure, diaphragmatic Emg activity, delay between the inspiratory activity initiation and positive pressure initiation, delay between the end of the inspiratory effort and the end of pressurisation.

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

BASIC_SCIENCE

Masking

SINGLE (Subject)

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Yes

Inclusion criteria

* Age \> 18 years * Healthy Subject without any chronic disease

Exclusion criteria

* Absence of consent * Pregnant

Design outcomes

Primary

Measure	Time frame
Comparison of breathing pattern during pressure support and Neurally Adjusted Ventilatory Assist (NAVA)	2h

Secondary

Measure	Time frame
Tidal volume evaluated by optoelectronic plethysmography	2h
Electrical diaphragmatic activity recorded by mechanical ventilator	2h

Countries

France

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Mar 21, 2026