Mobility Limitation
Conditions
Keywords
Resistance Exercise, Physical Activity, Mobility disability, Physical function, Muscle Strength, Older Adults, Mobility-Limited, Peak power and strength
Brief summary
This research study is looking to compare the effects of two uniquely different power training interventions (high force, lower velocity versus low force, high velocity) on changes in mobility status among older individuals at risk for mobility disability.
Interventions
BEHAVIORALHigh velocity low force Power Training
Lower Extremity high velocity power training performed at lower external resistance (40% of the 1 repetition maximum muscle strength). Leg and knee extension exercises were performed twice per week (3 sets of each exercise consisting of 10 repetitions).
BEHAVIORALLow velocity high force Power Training
Lower extremity low velocity power training performed at high external resistance (70% of the 1 repetition maximum muscle strength). Leg and knee extension exercises were performed twice per week (3 sets of each exercise consisting of 10 repetitions).
Sponsors
Tufts University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Investigator)
Eligibility
Sex/Gender
ALL
Age
70 Years to 85 Years
Healthy volunteers
Yes
Inclusion criteria
* Male and Female 70-85 yrs * Community dwelling * Short Performance Battery Score \>9 * BMI range 19-32 kg/m2 * Willingness to be randomized and come the laboratory for 20 weeks.
Exclusion criteria
* Acute or Terminal Illness * MI in previous 6 months, symptomatic coronary artery disease or congestive heart failure. * Upper or Lower extremity fracture in previous 6 months * Uncontrolled hypertension (150/90mmHg) * Neuromuscular diseases and drugs that affect neuromuscular function * Hormone replacement therapy * Participation in any regular endurance or resistance training exercise during previous 3 months
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Leg Extensor Muscle Power | Change from baseline to Week 16 | Leg extensor muscle power measured on pneumatic strength testing equipment at a external force consistent with 70% of the participant maximum leg extensor strength. |
Countries
United States
Participant flow
Participants by arm
| Arm | Count |
|---|---|
| High Velocity Low Force Power Training Lower extremity high velocity power training performed at lower external resistance (40% of the 1 repetition maximum muscle strength). Leg and knee extension exercises were performed twice per week (3 sets of each exercise consisting of 10 repetitions). | 25 |
| Low Velocity High Force Power Training Lower extremity low velocity power training performed at high external resistance (70% of the 1 repetition maximum muscle strength). Leg and knee extension exercises were performed twice per week (3 sets of each exercise consisting of 10 repetitions). | 27 |
| Total | 52 |
Baseline characteristics
| Characteristic | High Velocity Low Force Power Training | Low Velocity High Force Power Training | Total |
|---|---|---|---|
| Age, Continuous | 78.3 years STANDARD_DEVIATION 5 | 77.6 years STANDARD_DEVIATION 4 | 77.9 years STANDARD_DEVIATION 4.5 |
| Race and Ethnicity Not Collected | — | — | 0 Participants |
| Sex: Female, Male Female | 15 Participants | 18 Participants | 33 Participants |
| Sex: Female, Male Male | 10 Participants | 9 Participants | 19 Participants |
Adverse events
| Event type | EG000 affected / at risk | EG001 affected / at risk |
|---|---|---|
| deaths Total, all-cause mortality | — / — | — / — |
| other Total, other adverse events | 1 / 25 | 3 / 27 |
| serious Total, serious adverse events | 0 / 25 | 0 / 27 |
Outcome results
Primary
Leg Extensor Muscle Power
Leg extensor muscle power measured on pneumatic strength testing equipment at a external force consistent with 70% of the participant maximum leg extensor strength.
Time frame: Change from baseline to Week 16
Population: 4 participants dropped out of study before follow up
| Arm | Measure | Value (MEAN) | Dispersion |
|---|---|---|---|
| Power Training Performed at Low External Resistance | Leg Extensor Muscle Power | 32.9 Watts | Standard Error 13 |
| Power Training Performed at High External Resistance | Leg Extensor Muscle Power | 41.6 Watts | Standard Error 12 |