Renal Failure
Conditions
Keywords
renal failure, cardiology, contrast-induced nephropathy
Brief summary
Diagnosis of acute kidney injury (AKI) relies on a late marker, namely serum creatinine (SCr). New biomarkers are considered for early and sensitive detection of CIN. In particular, uNGAL has been used for early detection of AKI in the emergency department, after cardiopulmonary bypass or following CM administration. This study will be conducted to assess the possible value of urinary Neutrophil Gelatinase-Associated Lipocalin (uNGAL) as an early detector of contrast-induced nephropathy (CIN) in a large sized cohort of patients undergoing percutaneous coronary procedures (PCP) and whether or not uNGAL correlates with the volume of contrast medium (CM) used.
Detailed description
Methods. We will enroll all consecutive patients undergoing PCP with iomeprolum during a 3-month period at our institution. CIN will be defined as a ≥25% increase in SCr from baseline when measured 2-4 days after PCP. uNGAL will be measured at its peak with the Abbott ARCHITECT assay.
Interventions
None listed
Sponsors
University of Freiburg
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 90 Years
Healthy volunteers
No
Inclusion criteria
* All except patients with
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| to assess the value of uNGAL measurement 4 to 6 hours after PCP as a possible early detector of CIN | 4-6 hours after PCP | cf title |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| to study the relationship between the volume of contrast medium used for PCP and the uNGAL levels measured 4 to 6 hours thereafter | 4-6 hours after PCP | cf. title |
Countries
Switzerland
Outcome results
None listed