Effects of Glucose-fructose Drinks During Training on Lactate Transport

Effects of Glucose-fructose Drinks During Training on Lactate Transport and Oxidation and on Endurance Performance

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01610986

Acronym

LactEx

Enrollment

Registered

2012-06-04

Start date

2012-05-31

Completion date

2014-03-31

Last updated

2014-06-04

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Normal Physiology on Healthy Subjects

Keywords

Fructose, Exercise, Lactic acid, Monocarboxylic Acid Transporters

Brief summary

The purpose of this study is to determine whether glucose-fructose intake during training increases lactate transport and oxidation and improve endurance performance.

Detailed description

The study will enroll 24 healthy male volunteers. After baseline assessment of lactate transport and endurance performance, subjects will be randomized to either a 3-week intervention arm in which they will train with glucose-fructose intake during training, or to a control arm (water during training). After this 3-week intervention, lactate transport and endurance performance will be assessed again.

Interventions

DIETARY_SUPPLEMENTGlucose-fructose

0.8 g/h glucose and 0.5 g/h fructose during training

DIETARY_SUPPLEMENTWater

Only water intake during training

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

BASIC_SCIENCE

Masking

NONE

Eligibility

Sex/Gender

MALE

Age

18 Years to 30 Years

Healthy volunteers

Yes

Inclusion criteria

* healthy * age between 18 and 30 years * sedentary * BMI between 19 and 25 * blood pressure lower than 140/90 mmHg

Exclusion criteria

* smoking * consumption of more than 10g alcohol per day * cardiovascular history * electrographic abnormalities at rest * consumption of more than one can of soda per day or more than 60g sugars per day * any current drug treatment * consumption of drugs or illicit substances * diabetes mellitus * vegetarian * food intolerance * blood donation or participation to another study \<3 months before study inclusion

Design outcomes

Primary

Measure	Time frame	Description
Change in lactate transport	At baseline (before training) and after the 3-week training protocol	Measurement of lactate production, utilization, oxidation and clearance during a 90 min cycling exercise at 50% VO2 max (measured with 13C-lactate)

Secondary

Measure	Time frame	Description
Change in muscle monocarboxylate transporters (MCTs) expression and protein content	At baseline (before training) and after the 3-week training protocol	MCTs expression (mRNA) and protein content after muscle biopsy

Countries

Switzerland

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026