Colonic Adenomas
Conditions
Keywords
Adenoma Detection Rate, Anti-spasmotic drug
Brief summary
The primary aim of the study was to test if the administration of Hyoscine Butyl Bromide, at time of caecal intubation, increases the adenoma detection rate.
Detailed description
Outpatients referred for colonoscopy were screened for possible enrollment. Exclusion criteria included: glaucoma, benign prostatic hyperplasia or urinary obstruction, previous intestinal resection, ongoing therapy with tricyclic antidepressants, chronic renal failure and history of IBD. Eligible patients were randomized to receive either 20 mg/2ml of HBB i.v. or 2ml of saline i.v.; both the endoscopist and the patient were blind to the administered drug. The endoscopist was asked to inspect the right, transverse and left colon for at least 2 min for each segment. The number, size and location of polyps were recorded as well as the occurrence episodes of tachycardia (defined as bpm\>140). As indirect estimation of the amount of air retained in the abdomen at the end of the procedure, the DAC (difference in the abdominal circumference measured before and after colonoscopy) was also calculated. At discharge (at least 1 hour after colonoscopy) the bloating perceived by the patient was measured by means of a VA scale (range 0-100).
Interventions
DRUGHyoscine Butyl Bromide 20mg/2 ml i.v.
Hyoscine Butyl Bromide 20mg/2 ml i.v.is administered at time of caecal intubation
DRUGSaline 2 ml i.v.
Administration of Saline 2 ml at time of caecal intubation
Sponsors
Valduce Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
DIAGNOSTIC
Masking
DOUBLE (Subject, Caregiver)
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* outpatients referred for colonoscopy
Exclusion criteria
* glaucoma * benign prostatic hyperplasia or urinary obstruction * previous intestinal resection, * ongoing therapy with tricyclic antidepressants * chronic renal failure * history of IBD * participation other studies * unsedated colonoscopy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Effect of Hyoscine Butyl Bromide on Adenoma Detection Rate (ADR) | 5 months |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Tolerability of HBB | this outcome will be evaluated at the end of colonoscopy | As indirect estimation of the amount of air retained in the abdomen at the end of the procedure, the DAC (difference in the abdominal circumference measured before and after colonoscopy) was also calculated. At discharge (at least 1 hour after colonoscopy) the bloating perceived by the patient was measured by means of a VA scale (range 0-100). |
Countries
Italy
Contacts
Primary ContactEmanuele Rondonotti, MD
Outcome results
None listed