Preoperative Vitamin D for Post-thyroidectomy Hypocalcemia

Pre-operative Vitamin D Supplementation to Reduce Post-operative Hypocalcemia in Patients Undergoing Total Thyroidectomy: A Randomized Controlled Trial

Status

Withdrawn

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01609439

Enrollment

Registered

2012-06-01

Start date

Unknown

Completion date

Unknown

Last updated

2016-09-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hypocalcemia

Keywords

Permanent, temporary, hypocalcemia

Brief summary

The purpose of this study is to determine if pre-operative vitamin D supplementation lowers the incidence of post-operative transient or permanent hypoparathyroidism in patients undergoing total thyroidectomy.

Interventions

DRUGVitamin D

Vitamin D 800 units for 4 weeks preoperatively

DRUGPlacebo

Placebo

Study design

Allocation

RANDOMIZED

Intervention model

SINGLE_GROUP

Primary purpose

PREVENTION

Masking

TRIPLE (Subject, Investigator, Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Yes

Inclusion criteria

* Patients undergoing total thyroidecomty +/- CND * Adult (age \> or = 18)

Exclusion criteria

* Known chronic kidney disease * Known primary hyper or hypoparathyroidism * Known hypoalbuminemia * Concurrent use medications affecting calcium metabolism * Completion hemithyroidectomy

Design outcomes

Primary

Measure	Time frame	Description
Hypocalcemia	Transient (<72 hrs post-operatively)	Clinical signs and symptoms(paraesthesias, etc.) OR Laboratory evidence (ICa \< 0.9) Need for IV calcium supplementation

Secondary

Measure	Time frame	Description
Hypocalcemia	Permanent (>4 weeks)	ICa at 6 weeks and need for continued supplementation beyond 6 weeks post-op (i.e. 3 months follow-up post-operatively)

Countries

Canada

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026