Type 2 Diabetes Mellitus
Conditions
Keywords
endothelium, diabetes mellitus, oxidative stress
Brief summary
The study will determine whether acute and chronic consumption of a beverage containing erythritol will improve endothelial function in patients with type 2 diabetes mellitus.
Interventions
DIETARY_SUPPLEMENTErythritol-containing beverage
Orange flavored beverage containing erythritol
Sponsors
Cargill
Boston University
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
BASIC_SCIENCE
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
35 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
* Type 2 diabetes mellitus * Otherwise healthy
Exclusion criteria
* Pregnant * BMI\>35 kg/m2 * Long acting insulin treatment * Other major illness, drug abuse * Treatment with an investigational drug within 12 weeks * Treatment with dietary or vitamin supplements * Smoking within 3 months
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Brachial artery flow mediated dilation | Change from baseline at 28 days |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Brachial artery flow-mediated dilation | Change from baseline at 2 hours | Reactive hyperemia, carotid femoral pulse wave velocity, fingertip tonometry. |
| Reactive hyperemia | Change from baseline at 2 hours and 28 days | — |
| Carotid femoral pulse wave velocity | Change from baseline at 28 days | — |
| Fingertip tonometry | Change from baseline at 2 hours and 28 days | — |
| Urine F2 isoprostanes | Change from baseline at 28 days | — |
| C-reactive protein | Change from baseline at 28 days | — |
Countries
United States
Outcome results
None listed