Schizophrenia
Conditions
Keywords
cognitive rehabilitation, schizophrenia
Brief summary
Rationale: Cognitive deficits are a core feature in schizophrenia. Conventional treatments (antipsychotic medication and psychological treatments) have limited effects so cognitive remediation programs were designed to alleviate the problems. Interventions typically involve a variety of exercises in a paper and pencil or a computerized format with a growing number of specialized computer programs now being developed. However, many of these programs lack specificity which does not allow an individual's specific needs to be addressed. More targeted interventions might increase the effects of therapy so RECOS - COgnitive REmediation for Schizophrenia - was developed to fit this gap. Methods: This is a multicenter, randomized, controlled study comparing patients aged 18 to 45 years suffering from schizophrenia according to DSM-IV-TR. RECOS will be compared to an already validated program (CRT). 220 patients will be randomized as follows : * Arm 1 : RECOS (42 h) * Arm 2 : CRT (42 h) The recruitment is performed by psychiatrists in Lyon, Paris, Clermont-de-l'Oise, Niort, Bordeaux, Ville-Evrard and Lausanne.
Interventions
BEHAVIORALcognitive remediation
RECOS: cognitive remediation for schizophrenia CRT: cognitive remediation therapy
Sponsors
Centre hospitalier Saint Jean de Dieu - ARHM
Saint Anne's Hospital
Hôpital le Vinatier
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 45 Years
Healthy volunteers
No
Inclusion criteria
* men and women aged 18 to 45 years * French speaker or French schooling since 7 years * clinical stability * diagnosis of schizophrenia
Exclusion criteria
* visual or auditory disorder * history of neurological illness or trauma * alcohol or drug dependence * mental retardation
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change from baseline in executive functioning at week 12 | week 12 | BADS(Behavioral Assessement of Dysexecutive Functions) total score |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Change from baseline in executive functioning, attention, memory and visuospatial abilities at week 12 | week 12 | comprehensive neuropsychological assessment |
| Change from baseline in symptoms at week 12 | week 12 | PANSS (Positive And Negative Symptoms Scale) |
| Change from baseline in self-esteem at week 12 | week 12 | Rosenberg scale |
| Change from baseline in insight at week 12 | week 12 | Birchwood scale |
Outcome results
None listed