Laxative Compatibility
Conditions
Keywords
colonoscopy, bowel cleansing, bowel cleanness, efficiency, compatibility
Brief summary
For effective cleansing of the bowel prior to colonoscopy polyethylene glycol (e.g. macrogol) has widely been used in Germany. Usually patients have to drink between 4 an 6 liter of macrogol in a split dose (3 liter on the day before and 1 to 3 liter on the of the examination). One handicap of using polyethylene glycol is the occurence of nausea and vomiting which is due to the high amount of the laxativ and its bad taste. Therefore in a pilot study the investigators have detected a high fraction of patients who consider the cleansing procedure wich macrogol as very distressing. Thus patient acceptance of the colonoscopy procedure altogether is low. Since a few month sodium picosulfate/magnesium citrate is available for bowel cleansing in Germany. This preparation tastes better and needs less fluid intake. Usually 150 ml of sodium picosulfate/magnesium citrate are given twice within a 12 hour interval. Patients are instructed to drink plenty of water in addition to the laxative. In the mentioned pilot study the investigators found the cleansing procedure with picosulfate/magnesium citrate to be much more compatible compared to the macrogol regime. The effectiveness expressed by the cleanness of the bowel was equal in both groups. The investigators believe that a new protocol which contains sodium picosulfate/magnesium citrate instead of macrogol will benefit the patients by fewer abdominal side effects while cleanness of the bowel at the same time will be warranted. This presumption is the reason for the present study.
Interventions
PROCEDURECompatibility
Patients asses the compatibility of the bowel cleansing procedure
Sponsors
Technical University of Munich
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
DIAGNOSTIC
Masking
SINGLE (Investigator)
Eligibility
Sex/Gender
ALL
Age
18 Years to 90 Years
Healthy volunteers
Yes
Inclusion criteria
* Age \>= 18 * Scheduled for colonoscopy
Exclusion criteria
* No informed consent * ASA IV or V * Pregnancy
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Valuation very distressing | Just before colonoscopy up to 4 hours afterwards (0 to aprox 4 hours) | Patients will fill in a report in which they rate the stress triggered by the bowel cleansing procedure. The level ranges from 1 to 10 points. Valuations from 8 to 10 points will be considered as very distressing. |
Secondary
| Measure | Time frame |
|---|---|
| Colon cleanness | From the start to the end of colonoscopy, i.e. from 0 h to approximately 2 h |
Countries
Germany
Outcome results
None listed