Anhedonia, Diabetes Mellitus, Type 2, Hypercholesterolemia, Obesity
Conditions
Brief summary
The investigators purpose is to study how CBT (cognitive behavioral therapy)-based weight loss program affects on eating behavior, weight loss and risk factors for CHD (coronary heart diseases)and type 2 diabetes. Moreover, the investigators aim is to recognize subjects suffering from anhedonia (one of the core symptoms of depression, lack of pleasure) and follow how they benefit from the program in order to achieve maintained weight loss. Also, the associations between weight loss, physical activity and musculoskeletal disorders are studied.
Detailed description
Obesity is an increasing problem and effective weight loss methods are needed. The study is randomized follow-up study with 9 months intervention and three (3) years follow-up period. The study is organized in Oulu University Hospital, Department of Internal Medicine. Eighty (80)obese, 20-65 years, study subjects will be randomized into intervention or control group. The hypothesis of the CognObe study is: CBT (cognitive behavioral therapy)-based weight loss program is successful in sustained and favourable change in eating behavior and weight as well as decreased risk for coronary heart diseases or type 2 diabetes.
Interventions
BEHAVIORALCognitive behavioral therapy -based weight loss program
CBT-based program includes 20 group visits
Sponsors
Juho Vainio Foundation
Yrjo Jahnsson Foundation
Oulu University Hospital
University of Oulu
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
20 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
* BMI \> 30
Exclusion criteria
* other concurrent weight loss programs * disease which prevents weight loss * medication which affects on weight loss
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| change in weight | baseline, 9 months, 1,2 and 3 years | kilograms |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| change in eating behavior | baseline, 9 months, 1,2 and 3 years | emotional eating, uncontrolled eating, cognitive restraint, binge eating symptoms |
| change in total cholesterol,HDL, LDL,Trigly and glucose | baseline, 1,2 and 3 years | change in laboratory values |
| DNA | baseline | for genetic analyses |
| change in incretins | baseline, 12, 24 and 36 months | change in incretins |
Countries
Finland
Outcome results
None listed