Obesity
Conditions
Keywords
endothelial function, children, obesity, cardiovascular dysfunction, carotid intima media thickness, blood pressure, oral glucose tolerance test
Brief summary
The investigators hypothesize that cardiovascular and metabolic alterations due to obesity already manifest at childhood age. To identify these alterations and risk factors, the investigators have established a cohort of 177 healthy obese and lean control children, age ranging from 6y to 18y, for evaluation of cardiovascular and metabolic parameters, as well as quantification of biomarkers of obesity and inflammation. Follow-up analyses are planned after 2 years (completed) and additionally after 5, 7 and 9 years. In addition, the investigators will assess the effects of increased physical activity and exercise on cardiovascular function.
Interventions
None listed
Sponsors
German Research Foundation
University of Leipzig
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
6 Years to 25 Years
Healthy volunteers
Yes
Inclusion criteria
* height -2 to +2 SDS * pubertal stage adequate for age * no medications * written consent of guardians and children≥12y * weight ≥ -2 SDS
Exclusion criteria
* secondary/syndromal obesity * known existing hypertension * chronic disease (eg. errors of metabolism) * acute illness (eg. respiratory tract infection) * previous hypertensive or antidiabetic treatment- weight loss attempts 6 weeks prior to assessment
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| cardiovascular dysfunction | 7 years | Assessment of endothelial function, carotid intima media thickness, blood pressure, echocardiography, exercise capacity, insulin sensitivity by oGTT, serum lipids |
Countries
Germany
Outcome results
None listed