Colorectal Cancer, Lung Cancer
Conditions
Brief summary
The goal of the investigators study is to investigate the role of a hormone named Activin A (ActA) in the development of the skeletal muscle atrophy caused by cancer. According to the investigators hypothesis, ActA could be released by the tumor and activate a muscle atrophy gene program. To answer this question, the investigators plan first to compare circulating levels of ActA in cancer patients with and without cachexia. In a second step, the investigators would like to assess whether ActA circulating levels are predictive for the development of cachexia and short survival.
Interventions
OTHERblood tests and muscular biopsies
blood tests and muscular biopsies
Sponsors
Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
BASIC_SCIENCE
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* 18-year-old or older * Colorectal or lung cancer demonstrated by histology or cytology * New diagnosis or new recurrence * Expected survival more than 3 months * No previous history of other cancer in the last 5 years * No pregnancy or lactation * Signed informed consent
Exclusion criteria
* Non-caucasian * Major digestive malabsorption * Major depression * Artificial nutrition * Height doses of steroids (\>1 mg/kg hydrocortisone equivalent) * Hyperthyroidism * Other causes of malnutrition * Expected survival less than 3 months * Severely impaired walking * Anticoagulants or antiplatelet therapy * Disability or medical condition which might prevent the compliance to the protocol * Any conditions which may prevent the compliance to the protocol * Performance status ECOG \> ou = 4 * Participation to other clinical studies
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Circulating Activin A level | 2 years |
Secondary
| Measure | Time frame |
|---|---|
| Body mass index | 2 years |
| Mid arm muscle circumference calculated by the triceps skinfold and the mid arm circumference | 2 years |
| Dietary assessment measured by SNAQ score and 3-Day intake | 2 years |
| Muscle strength as measured by grip strength | 2 years |
| Quality of life as assessed using the QLQ-C30 | 2 years |
| Body composition measured by bioimpedance | 2 years |
Countries
Belgium
Outcome results
None listed