Membrane Shedding During Septic Shock

Membrane Shedding During Severe Sepsis and Septic Shock: Pathophysiological and Clinical Relevance

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT01604551

Enrollment

100

Registered

2012-05-23

Start date

2003-05-31

Completion date

2011-12-31

Last updated

2012-06-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Septic Shock

Brief summary

Microparticles (MPs) result from plasma cell membrane remodeling and shedding after cell stimulation or apoptosis. MPs are know recognized as a pool of bioactive messengers with emerging role in pathophysiology of immune and cardiovascular diseases. MPs have been characterized during septic shock and may contribute to dissemination of pro-inflammatory and procoagulant mediators. This is a prospective observational study of circulating MPs and blood coagulation in 100 septic shock patients admitted in 3 tertiary hospitals medical ICU at baseline (D1), D2, D3, D4 and D7.

Interventions

None listed

Study design

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to 85 Years

Healthy volunteers

Inclusion criteria

* Septic shock * Informed consent

Exclusion criteria

* Class IV heart failure * Child-Plugh grade C cirrhosis * Cancer under active treatment * BMI\>35 kg/m² * Moribund patient * DNR decision

Countries

France

Outcome results