Bispectral Index Monitoring, General Anesthesia, Total Intravenous Anesthesia
Conditions
Keywords
total intravenous anesthesia, Bispectral index monitoring, propofol, remifentanil
Brief summary
The BIS is influenced by multiple parameters, such as age,gender, body weight, height, muscle relaxants, hepatic function, co-administered drugs, surgical stimulation, but is thought to be influenced mainly by propofol and remifentanil infusion dose. As such, the investigators postulate that the BIS value could be predicted by the estimated effects-site concentration of propofol and remifentanil, and try to establish a multiple linear regression model for predicting BIS value.
Detailed description
Total intravenous anesthesia is commonly performed with propofol and remifentanil now-a-days. The combination of these two drugs can achieve the rapid loss of consciousness and analgesia,as the onset and recovery time of these two drugs are very fast within one to three minutes. However, the problem of intraoperative awareness necessitate the monitoring of anesthetic depth, which is commonly performed with Bispectral index (BIS). BIS is a display of number from zero to one hundred which quantify the degree of sedation and hypnosis by anesthetics by analyzing the electroencephalogram. However, it is limited in neurosurgery in which the surgical field is near the forehead where the BIS probe is attached. Furthermore, it is also limited in surgery with prone position. The BIS is influenced by multiple parameters, such as age,gender, body weight, height, muscle relaxants, hepatic function, co-administered drugs, surgical stimulation, but is thought to be influenced mainly by propofol and remifentanil infusion dose. As such, we postulate that the BIS value could be predicted by the estimated effects-site concentration of propofol and remifentanil, and try to establish a multiple linear regression model for predicting BIS value.
Interventions
None listed
Sponsors
Samsung Medical Center
Study design
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
20 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
* Those undergoing gynecologic or urologic surgery with general anesthesia with total intravenous anesthesia * Adult patients with more than 20 yrs. * American Society of Anesthesiologists Class I or II.
Exclusion criteria
* Those with unstable hemodynamics * Those who can not undergo Bispectral index monitoring * Those with previous history of stroke
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Bispectral index value | every 10 min after anesthetic induction | Bispectral index value after anesthetic induction every 10 minutes interval until the end of surgery |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Propofol concentration | every 10 min after anesthetic inducton | estimated propofol effect-site concentration displayed in target-centered infusion pump every 10 minutes interval |
| Remifentanil concentration | every 10 minutes after anesthetic induction | estimated remifentanil effect-site concentration displayed in target-centered infusion pump every 10 minutes interval |
Countries
South Korea
Contacts
Primary ContactSangmin M. Lee, MD, PhD
Backup ContactWon Ho Kim, MD
Outcome results
None listed