Female Infertility
Conditions
Brief summary
This study evaluates the effects of different therapies in ovulation induction in Intrauterine Insemination Cycles.
Interventions
DRUGMeropur 150 a day
one subcutaneous injection a day
DRUGGonal-f 150 plus Luveris 150
one subcutaneous injection a day
Sponsors
Catholic University of the Sacred Heart
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
FEMALE
Age
35 Years to 41 Years
Healthy volunteers
Yes
Inclusion criteria
* women with story of infertility sine causa and mild-moderate male factor * regular ovulatory menstrual cycles * BMI ≤27 kg/m2 * normal day 3 hormonal pattern * bilateral tubal patency
Exclusion criteria
* mono/bilateral tubal occlusion, * severe male factor * polycystic ovarian syndrome or any systemic disease or endocrine or metabolic abnormalities * pelvic inflammatory disease * endometriosis * sexual organ malformations * neoplasms or breast pathology incompatible with gonadotropin stimulation.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| ongoing pregnancy rate | 12 weeks |
Secondary
| Measure | Time frame |
|---|---|
| number of cancelled cycles for low or no response, the number of interrupted cycles for high risk of OHSS and multiple pregnancies | 30 days |
Other
| Measure | Time frame |
|---|---|
| duration of stimulation, total gonadotropin dose, number of midsize follicles, dominant follicles, E2 levels, endometrial thickness on hCG day, Progesterone levels, endometrial thickness on the midluteal phase. | 30 days |
Countries
Italy
Outcome results
None listed