Neural Activation and Connectivity in Response to Exercise and Cognitive Training

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT01603771

Acronym

NAC

Enrollment

Registered

2012-05-23

Start date

2011-06-30

Completion date

2012-12-31

Last updated

2014-09-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Neural Connectivity

Keywords

Adult, Exercise, Cognition, MRI

Brief summary

The goal of this pilot study is to evaluate whether healthy, sedentary older adults have increased activation of specific brain areas, in response to exercise and cognitive training, in comparison to a control group, and whether improvements in psychometric test performance are related to increased activation of brain networks. Participants, between age 55-75 years will be recruited from an ongoing study of exercise and cognitive training, to undergo Blood Oxygen Level Dependent (BOLD) functional magnetic imaging (fcMRI).

Interventions

OTHERBlood Oxygen Level Dependent (BOLD) functional magnetic imaging (fMRI)

All participants complete MRI scans at baseline and at the end of month 6. Scanning sessions last approximately 30 minutes each and consist of two components: (1) High resolution T1-weighted MPRAGE anatomic images to provide detailed anatomy and maximum gray-white matter contrast for images and to allow any estimate of regional or whole-brain volume, and (2) Resting BOLD functional images to allow assessment of the functional connectivity in large scale networks.

Study design

Observational model

CASE_CONTROL

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

55 Years to 75 Years

Healthy volunteers

Yes

Inclusion criteria

* meet the inclusion criteria for the parent study, Combining Exercise and Cognitive Training to Improve Everyday Function (EXACT) study (Unique Protocol ID 201102416).

Exclusion criteria

* currently taking chronic psychotropic medication, beta blockers, or calcium channel blockers * contraindication to MRI scanning * inability to complete MRI scans in closed scanner

Design outcomes

Primary

Measure	Time frame
Functional connectivity of large-scale brain networks as seen through Blood Oxygen Level Dependent (BOLD) functional magnetic resonance imaging (fMRI)	Change in connectivity measurements between baseline and 6 months

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026