Comparison of Morphine and Fentanyl/Midazolam in Intensive Care Unit

Sedation and Analgesia in Intensive Care: Comparison of Morphine and Fentanyl/Midazolam

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01602640

Enrollment

Registered

2012-05-21

Start date

2009-01-31

Completion date

2012-03-31

Last updated

2012-05-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Respiratory Failure

Keywords

sedation, critical care, morphine, fentanyl, analgesic based sedation

Brief summary

Hypothesis: Morphine infusion decreases time to mechanical ventilation weaning and extubation, as compared to the combination of fentanyl and midazolam in critically-ill patients.

Interventions

DRUGMorphine infusion

Conventional dose

DRUGFentanyl and Midazolam infusion

Conventional dose

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

SUPPORTIVE_CARE

Masking

SINGLE (Subject)

Eligibility

Sex/Gender

ALL

Age

18 Years to 80 Years

Healthy volunteers

Inclusion criteria

* Adults admitted to ICU requiring mechanical ventilation Informed consent

Exclusion criteria

* Less than 18 years old * Consent denial

Design outcomes

Primary

Measure	Time frame
Time from sedation discontinuation to first T-Tube time from sedation	12-120 hours

Secondary

Measure	Time frame
Time from sedation discontinuation to extubation time from sedation	12-180 hours

Countries

Colombia

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026