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Twitter-enabled Mobile Messaging for Smoking Relapse Prevention

Twitter-enabled Mobile Messaging for Smoking Relapse Prevention

Status
Completed
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT01602536
Enrollment
160
Registered
2012-05-21
Start date
2012-01-31
Completion date
2014-06-30
Last updated
2024-10-31

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Smoking

Keywords

twitter, quit smoking, smoking cessation, social media, peer support

Brief summary

We conducted a two-arm (test vs. control, N=160) randomized controlled trial of small, private, online support groups for quitting smoking with 20 people per group who were seeking to quit smoking. A novel feature was a bot (auto-messenger) that posted a daily cessation-related discussion topic in each group, timed to the group's quit date.

Detailed description

Smoking relapse rates remain high, innovative strategies are needed to lower them, and web-based social networking may help like Twitter. This developmental research examined whether providing virtual (web-based) social support to smokers, through Twitter-enabled interactive peer texting, could help smokers quit and avoid relapses. Twitter is a free social networking and micro-blogging service, one of the most advanced and novel technologies available today that can provide social support to smokers, and it provides free texting to groups. It is global and has many features that are associated with treatment success including interactive, multi-way, live messaging and mobile accessibility, because the messages go instantly to mobile phones and to the web. It can provide an innovative way to reach smokers who might otherwise not seek treatment, and it can be extended to other health domains. From June 2012 through 2014, we conducted a two-condition randomized controlled trial. All participants in this trial (N=160) received 8 weeks of free nicotine patches, referral to the NCI's online Smokefree.gov Quit Guide, and instruction to set a quit date within 1 week of study start. Participants were also randomly assigned at the individual level to one of two conditions: (1) a virtual or online quit-smoking group on Twitter where the group members were instructed to use interactive peer messaging to help them quit and stay quit, or (2) a control group condition where the group members were not given this instruction or a Twitter group. In total, there were 4 Twitter groups and 4 control groups with 20 smokers randomly assigned to each group (i.e., N=80 test, N=80 control). In the Twitter groups, a bot (auto-messenger) posted a daily cessation-related discussion topic in each group, timed to the group's quit date. The primary outcome was self-reported 7-day point prevalence abstinence that was sustained at 7, 30 and 60 days after the quit date. Participants' posts, their virtual and face-to-face social networks, and several other possible mediating and moderating variables were also analyzed.

Interventions

BEHAVIORALsmoking cessation aides

All participants will receive 8 weeks of free nicotine patches, referral to the NCI's online Smokefree.gov Quit Guide, and instruction to set a quit date within 8 days of study start.

BEHAVIORALTwitter

Twitter quit-smoking group

Sponsors

National Institute on Drug Abuse (NIDA)
CollaboratorNIH
University of California, Irvine
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
NONE

Eligibility

Sex/Gender
ALL
Age
18 Years to 59 Years
Healthy volunteers
Yes

Inclusion criteria

* must have smoked 100 cigarettes during their lifetime * must currently smoke 5 or more cigarettes a day * must be in the preparation stage of quitting smoking * ages 18-59 years * English speaking * have a mobile phone with an unlimited texting plan and internet access * use text messaging at least once a week * use Facebook daily * have an active email account * live in the continental USA

Exclusion criteria

* a medical condition that is contra-indicated for nicotine replacement therapy: * pregnant * breast feeding * a recent heart attack * an irregular heartbeat * high blood pressure not controlled with medication * skin allergies to adhesive tape or serious skin problems * taking a prescription medicine for depression or anxiety * use drugs or marijuana regularly * live in the same household with another participant

Design outcomes

Primary

MeasureTime frameDescription
Self-reported 7-day Point Prevalence Abstinence From Smoking That Was Sustained at 60 Days After the Quit Date60 days after quit dateself-reported 7-day point prevalence abstinence from smoking that was sustained at 60 days after the quit date, based on survey

Secondary

MeasureTime frameDescription
Level of Engagement Based on Tweet Volume100 days totallevel of engagement based on tweet volume which is observed in support groups

Countries

United States

Participant flow

Participants by arm

ArmCount
Twitter
Experimental participants are assigned a 20-person twitter quit-smoking group to interact with, are instructed to use Twitter-enabled interactive peer messaging,and are sent daily messages to encourage interaction. The baseline intervention 'smoking cessation aides' is also provided. smoking cessation aides: All participants will receive 8 weeks of free nicotine patches, referral to the NCI's online Smokefree.gov Quit Guide, and instruction to set a quit date within 8 days of study start. Twitter: Twitter quit-smoking group
80
Control
Control participants are not assigned to a twitter group. The baseline intervention 'smoking cessation aides' is also provided. smoking cessation aides: All participants will receive 8 weeks of free nicotine patches, referral to the NCI's online Smokefree.gov Quit Guide, and instruction to set a quit date within 8 days of study start.
80
Total160

Baseline characteristics

CharacteristicTwitterControlTotal
Age, Continuous
age
35.35 years
STANDARD_DEVIATION 10.55
36.00 years
STANDARD_DEVIATION 9.16
35.68 years
STANDARD_DEVIATION 9.85
Sex: Female, Male
Female
55 Participants61 Participants116 Participants
Sex: Female, Male
Male
25 Participants19 Participants44 Participants

Adverse events

Event typeEG000
affected / at risk
EG001
affected / at risk
deaths
Total, all-cause mortality
0 / 800 / 80
other
Total, other adverse events
0 / 800 / 80
serious
Total, serious adverse events
0 / 800 / 80

Outcome results

Primary

Self-reported 7-day Point Prevalence Abstinence From Smoking That Was Sustained at 60 Days After the Quit Date

self-reported 7-day point prevalence abstinence from smoking that was sustained at 60 days after the quit date, based on survey

Time frame: 60 days after quit date

ArmMeasureValue (COUNT_OF_PARTICIPANTS)
TwitterSelf-reported 7-day Point Prevalence Abstinence From Smoking That Was Sustained at 60 Days After the Quit Date26 Participants
ControlSelf-reported 7-day Point Prevalence Abstinence From Smoking That Was Sustained at 60 Days After the Quit Date14 Participants
Secondary

Level of Engagement Based on Tweet Volume

level of engagement based on tweet volume which is observed in support groups

Time frame: 100 days total

Population: all participants were observed to assess their tweeting (posting) behavior

ArmMeasureValue (MEAN)Dispersion
TwitterLevel of Engagement Based on Tweet Volume58.86 social media postsStandard Deviation 68.02
ControlLevel of Engagement Based on Tweet Volume0 social media postsStandard Deviation 0

Source: ClinicalTrials.gov · Data processed: Mar 5, 2026