Stroke
Conditions
Keywords
Ischemic stroke, direct current stimulation, motor threshold, National institutes of Health Stroke Scale, Barthel index scale, Measurement of motor power improvement
Brief summary
The purpose of this study will to compare the long-term effect of anodal versus cathodal transcranial direct current stimulation (tDCS) on motor recovery in subacute stroke patients. Forty patients with subacute ischemic stroke will randomly assigned to one of three groups: Anodal, Cathodal and Sham. Each group will receive tDCS at an intensity of 2mA for 25 minutes daily for 6 consecutive days over the affected (Anodal, Sham) or unaffected (Cathodal) motor cortex. Patients will be assessed with National Institutes of Health Stroke Scale (NIHSS), the Barthel index (BI) and the Medical Research Council (MRC) muscle strength scale at baseline, after end of the 6th tDCS session, and then 1, 2 and 3 months later. Motor cortical excitability will be measured at baseline and after the 6th session in both hemispheres.
Interventions
The anodal group will receive tDCS for 25 minutes at 2mA daily for 6 consecutive days on the affected hemisphere.
PROCEDUREtranscranial direct current stimulation (Cathodal)
The Cathodal group will receive tDCS for 25 minutes at 2mA daily for 6 consecutive days on the unaffected hemisphere.
The sham group will receive sham tDCS for 25 minutes daily for 6 consecutive days on the affected hemisphere.
Sponsors
Dina Hatem Elhammady
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
40 Years to 70 Years
Healthy volunteers
No
Inclusion criteria
* acute hemiparesis with single thromboembolic non-hemorrhagic infarction documented by magnetic resonance imaging (MRI) * Accept to participate in the study
Exclusion criteria
* extensive infarction (taking all territories of middle cerebral artery) * severe flaccid hemiplegia * head injury * Any other neurological disease other than stroke * previous administration of tranquilizer * patients who are unable to give informed consent because of severe aphasia, or cognitive deficit. * Patients with no motor evoked response recorded from First Dorsal Interosseus (FDI) muscle of the affected hand
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Motor power improvement | 3 Months | improvement in the motor power of paretic patient as measured in one proximal and one distal muscle group testing in upper (shoulder abduction + hand grip) and lower limbs ( hip flexion + toes dorsiflexion). |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Motor cortical excitability | 1 Month | The difference in the motor cortical excitability (RMT, AMT) before and after tDCS |
Countries
Egypt
Outcome results
None listed