Urinary Tract Infection
Conditions
Keywords
Urinary Tract Infection, Bacteriuria, Pyuria, Prostatitis, Intermittent Catheterization, Spinal Cord Injuries, Residual Urine
Brief summary
The purpose of this prospective study is to investigate the association between the amount of residual urine and asymptomatic bacterial prostate infection with the occurrence of recurrent (\>2 /year) symptomatic urinary tract infections in patients suffering from chronic (\> 1 year) spinal cord injury (SCI) and neurogenic lower urinary tract dysfunction performing intermittent catheterization. The following hypotheses will be tested: 1. The amount of residual urine after intermittent catheterization is significantly greater in SCI patients suffering from frequent (\>2 /year) urinary tract infections compared to those without. 2. The incidence of asymptomatic bacterial prostate infections is significantly higher in SCI patients suffering from frequent (\>2 /year) urinary tract infections compared to those without.
Detailed description
To investigate the association between the amount of residual urine and asymptomatic bacterial prostate infection with the occurrence of recurrent (\>2 /year) symptomatic urinary tract infections in patients suffering from chronic (\> 1 year) spinal cord injury (SCI) and neurogenic lower urinary tract dysfunction performing intermittent catheterization, patients perform self-catheterization twice (before and after urodynamic testing. After each catheterization, residual urine is assessed by ultrasound. Prior to urodynamic testing, prostate massage is performed, bacterial cultures of the fluid and the urine are initiated and the results of these cultures will be analysed .
Interventions
OTHERsonographic assessment of residual urine, urine culture
residual urinary volume assessed by ultrasound after bladder catheterization urinary cultures taken before and after prostate massage
Sponsors
Swiss Paraplegic Research, Nottwil
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
MALE
Age
18 Years to 70 Years
Healthy volunteers
No
Inclusion criteria
* male patients with chronic (\> 1 year) spinal cord injury * bladder management by intermittent catheterization
Exclusion criteria
* symptomatic urinary tract infection * prostate pathology * immunodeficiency * antibiotic therapy * missing informed consent
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| amount of residual urine | change from self-catheterization 10 minutes before and 10 minutes after urodynamic assessment | determined by ultrasound |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| bacteriuria | 5-10 minutes before and after prostate massage | urine dip stick |
| number of leucocytes in urine | 5-10 minutes before and after prostate massage | urine dip stick |
| number of erythrocytes in urine | 5-10 minutes before and after prostate massage | urine dip stick |
| bacterial prostate infection | 5-10 minutes before and after prostate massage | urinary culture |
| type of neurogenic bladder dysfunction | day 0 | — |
| type of catheter used for intermittent catheterization | day 0 | — |
| annual rate of symptomatic urinary tract infections | day 0 | — |
| patient characteristics | day 0 | age |
Countries
Switzerland
Outcome results
None listed