Blood Pressure, Human Metabolomic Responses to Plant Foods
Conditions
Keywords
metabolomics, nutri-metabolomics, plant food, blood pressure
Brief summary
Vegetable is well known to prevent chronic disease,however, the mechanism of its nutrients and non-nutrients still remains to be discovered.We design a feeding study which provides plant foods to subjects one by another and monitoring metabolomic changes up to 7 hours.The goal of this study is to establish a protocol for documenting metabolomics response to plant foods and try to characterize plant foods in terms of their anti-hypertension potentials with metabolomic profiling information.
Interventions
OTHERLow phytochemical diet(LPD), high phytochemical diet(HPD)
LPD is a basal diet which low in soy,vegetable and fruit and other plant food to approach low phytochemical. HPD is the diet which add two serving test vegetable in the lunch of LPD.
Sponsors
Tri-Service General Hospital
National Health Research Institutes, Taiwan
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 60 Years
Healthy volunteers
Yes
Inclusion criteria
* Age :18-60 years * Body Mass Index :18.5-30(kg/m2) * Non-smoking,alcohol abusing,and other bad hobbies
Exclusion criteria
* With regular drug intake e.g. anti-hypertensive or antidiabetes drug or history of immune, hepatic and metabolic disease or other unsuitable disorders e.g. cancer. * unwilling to stop regular food supplement e.g. vitamins, herb * cannot cooperate with designed diet * History of urinary tract infection or antibiotic use within the previous 3 month
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| blood pressure | one day | fasting, before lunch,and every 1 hr after lunch |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| metabolomic profile of serum and urine | one day | serum sample will be measure fasting ,before lunch,and every 1 hr after lunch;urine sample will be measure fasting ,before lunch(0hr),0-2 hr,2-4hr 4-7hr after lunch |
Countries
Taiwan
Outcome results
None listed