The Differential Pattern of Deposition of Nano Particles in the Airways of Exposed Workers

The Differential Pattern of Deposition of Nano Particles in the Airways of Exposed Workers (Nanoexposure)

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT01599845

Acronym

Nanoexposure

Enrollment

Registered

2012-05-16

Start date

2012-05-31

Completion date

2013-05-31

Last updated

2012-05-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Inadequate or Impaired Respiratory Function

Keywords

Lung, Alveoli, Nanoparticles, Particulate matter, Exhaled breath condensate, Induced sputum, Forced expiratory volume, Force vital capacity

Brief summary

Investigation of the differences between the levels of extracellular and intracellular nano-particles in workers exposed to environmental particles during their employment to enhance understanding the process of penetration of the particles to respiratory epithelial cells.

Detailed description

This study investigates the following questions: Does occupational exposure to nanoparticles influence permeation of such particles to respiratory airways? Is there a correlation between the levels of nanoparticles in sample biological fluids of the patients and their pulmonary functions. Is there a correlation between the levels of nanoparticles in sample biological fluids of the patients and respiratory tract infections. The study protocol includes the following steps: Initial interview of the patient Measurement of nanoparticles in samples of exhaled breath condensate using NanoSight LM 20 Measurement of nanoparticles in induced sputum. And finally examination of the relationship between the measured parameters and the indices of pulmonary infection, and pulmonary function as measured by the pulmonary department of the TASMC.

Interventions

None listed

Study design

Observational model

CASE_ONLY

Time perspective

CROSS_SECTIONAL

Eligibility

Sex/Gender

ALL

Age

20 Years to 60 Years

Healthy volunteers

Yes

Inclusion criteria

* Adults over 20 years of age who visit Ichilov Hospital for medical complaints/inquiries regarding respiratory tract. * Study population is composed of people who are exposed to environmental particles form industrial sources. * Informed consent is requested from each subject.

Exclusion criteria

* Unemployed individuals. * Individuals who are not working in industrial jobs, such as office workers and secretaries.

Design outcomes

Primary

Measure	Time frame	Description
Analysis of the size distribution of nano-particles in exhaled breath condensate	One year	Each subject will be examined once. The total time for collection of data is estimated as about one year.

Contacts

Primary ContactYehuda Schwarz, M.D.

schwarz.reot@gmail.com03-6973774

Outcome results