Abdominal Abscess, Tissue Plasminogen Activator
Conditions
Keywords
abscess, tPA
Brief summary
The objective of this study is to evaluate the utility of fibrinolysis when draining an abdominal abscess as defined by length of stay after drainage.
Detailed description
The hypothesis is that fibrinolysis of a abscess will shorten hospital stay compared to drainage alone.
Interventions
PROCEDURETissue plasminogen activator abscess flush
Thirteen ml of 10% tPA in saline at time of drain and twice daily thereafter.
PROCEDURESaline flush of abscess
Thirteen ml of saline is used to flush abscess at time of drain placement and twice daily thereafter.
Sponsors
Children's Mercy Hospital Kansas City
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
No minimum to 17 Years
Healthy volunteers
No
Inclusion criteria
* Patients under age 18 found to have an abscess in their abdomen related to perforated appendicitis that requires a drain either prior to or after appendectomy.
Exclusion criteria
* Patients with known immune deficiency per medical record review * Patients with another condition affecting surgical decision making or recovery * Patients with drain unable to be placed
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Length of hospital stay | 1-2 weeks | Length of time required for meeting discharge criteria |
Countries
United States
Outcome results
None listed