Cerebrovascular Autoregulation During and After Liver Transplantation

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT01597102

Acronym

dARICULtx

Enrollment

Registered

2012-05-11

Start date

2012-01-08

Completion date

2021-03-31

Last updated

2020-06-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cerebrovascular Disorders, Encephalopathy, Hepatic, Liver Failure

Keywords

encephalopathy, hepatic, autoregulation, cerebrovascular, liver failure, liver transplantation

Brief summary

The cerebrovascular autoregulation (AR) is impaired in patients with hepatic encephalopathy. Patients with the indication to liver transplantation mostly have mild to severe hepatic encephalopathy. Transplantation should recover the encephalopathy. The aim of the study is to investigate the AR during liver transplantation, with the questions if the AR is impaired at the beginning of surgery and if there are changes in AR. For follow up the AR will be measured at the first days after transplantation at the ICU.

Detailed description

The cerebrovascular autoregulation (AR) will be measured using transcranial doppler and calculating the index of autoregulation Mx. This measurement is continuous with online calculation. So, the possible changes over the whole time of surgery can be detected. Furthermore, the measurement of AR at the ICU will be performed daily at the same time over a measurement period of 60 Minutes and the time course of AR after liver transplantation will be described.

Interventions

OTHERNo interventions

No intervention is planned in this study

Study design

Observational model

OTHER

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* liver transplantation * age \> 18 years

Exclusion criteria

* sepsis * preexisting cerebral diseases * traumatic brain injury * pregnancy

Design outcomes

Primary

Measure	Time frame	Description
Changes of cerebrovascular autoregulation during liver transplantation	During the surgery	Measuring cerebrovascular autoregulation during the whole liver transplantation and compare the index of AR at the beginning with index of AR Mx after reperfusion of the transplantated liver

Secondary

Measure	Time frame	Description
Time course of cerebrovascular autoregulation after liver transplantation	First 4 days after transplantation	Meaurement of cerebrovascular autoregulation daily for the first 4 days and calculating a time course

Countries

Germany

Contacts

Primary ContactPatrick Schramm, MD

schrammp@uni-mainz.de00496131176755

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026