Obesity
Conditions
Keywords
Caloric restriction, Obesity, Gastric bypass, Resting metabolic rate
Brief summary
Studies in overweight and obese subjects show a decline in resting metabolic rate (RMR) even after moderate caloric restriction. Yet the onset and course of such a metabolic adaption is still unclear. Lower resting metabolic rates were also reported after gastric banding bariatric surgery but have not yet been investigated in subjects after gastric bypass. The purpose of this study is to investigate the consequences on resting metabolic rate in subjects with obesity after moderate caloric restriction or gastric bypass.
Interventions
BEHAVIORALCaloric restriction
Subjects receive caloric restriction as calculated by an online weight management program and are followed-up for resting metabolic rate.
PROCEDUREGastric bypass
Subjects with a planned gastric bypass surgery are followed-up for resting metabolic rate.
Sponsors
Hospital Barmherzige Schwestern Vienna
KiloCoach e.U.
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 60 Years
Healthy volunteers
No
Inclusion criteria
* BMI ≥30 kg/m2
Exclusion criteria
* Marked weight reduction in the last 2 years (\>5% of initial body weight) * Recent extreme fasting (during the last month) * Manifest eating disorders (assignment to a specialist for eating disorders) * Severe psychiatric disorders requiring treatment * Pregnancy, lactation
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Resting metabolic rate | 24 weeks |
Secondary
| Measure | Time frame |
|---|---|
| Body composition (muscle mass, fat mass) | 24 weeks |
| Body Mass Index | 24 weeks |
| Caloric restriction | 24 weeks |
| Weight loss | 24 weeks |
Countries
Austria
Outcome results
None listed