Infertility
Conditions
Keywords
Fertilization failure, calcium ionophore, SrCl2
Brief summary
Artificial oocyte activation with strontium chloride or calcium ionophore improves fertilization, embryo quality, pregnancy and delivery rate in women who showed complete fertilization failure or low fertilization rates
Interventions
OTHERCalcium ionophore
Oocytes were activated with calcium ionophore after ICSI
OTHERStrontium chloride (SrCl2)
Oocytes were activated with strontium chloride after ICSI
Sponsors
Maria Fertility Hospital
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Eligibility
Sex/Gender
FEMALE
Age
20 Years to 45 Years
Healthy volunteers
No
Inclusion criteria
* Fertilization rate was less than 30% after conventional ICSI. * Fertilization rate was less than 50% after ICSI with calcium ionophore. * Repeated complete fertilization failure or low fertilization rates following ICSI in previous cycles
Exclusion criteria
* Fertilization rate was more than 30% after conventional ICSI * Fertilization rate was more than 50% after ICSI with calcium ionophore. * Successful pregnancy and delivery after ICSI in previous cycles
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Fertilization rate | 18 hours |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Embryo quality | 3 Days | — |
| Pregnancy and Implantation rates | 2 months | — |
| Assessment of Infant health care | birth and at 3, 6, 12, 24, 36, 60, and 72 months | This assessment is according to the standard set by the National Health Insurance Service (NHIS) in Korea. |
Countries
South Korea
Outcome results
None listed