Surgery
Conditions
Brief summary
The skin conductance algesimeter (Pain Monitor™, Med-Storm Innovation AS, NO-0264 Oslo, Norway)) reflects the sympathetic nervous system by the measurement of the skin conductance of the palm of the hand. SCA detects nociceptive pain fast and continuously, specific to the individual, with higher sensitivity and specificity than other available objective methods. The skin conductance response to a calibrated noxious stimulus varies among patients. It defines two types of people depending on its magnitude. The investigators assume that the importance of skin conductance response to a noxious stimulus predicts the occurrence of chronic pain in patients operated by thoracotomy.
Interventions
DEVICEPain Monitor
Measurement of cutaneous conductance
Sponsors
Hopital Foch
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 75 Years
Healthy volunteers
No
Inclusion criteria
* adult patients of both sexes * planned pulmonary resection for cancer performed by a posterolateral thoracotomy * thoracic epidural analgesia
Exclusion criteria
* pregnancy, * morbid obesity, * insulin-dependent diabetes with dysautonomia, * inability to proceed with anesthesia using the BIS signal, * known allergy to remifentanil, propofol, atracurium or to levobupivacaine, * contra-indication to nefopam * contra-indication to ketoprofen
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Prediction of chronic pain | one year after surgery | Prediction of chronic pain by the measurement of skin conductance |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Prediction of the postoperative pain | 5 days postoperatively | Prediction of the postoperative pain by the measurement of skin conductance. Postoperative pain is assessed (pain score) at least twice each day at rest and during mobilisation. |
| Prediction of the postoperative antalgic requirement | 5 days postoperatively | Prediction of the postoperative analgesic requirement by the measurement of skin conductance. The analgesic requirement is evaluated by the amount of epidural analgesics. |
| Prediction of the postoperative antalgic requirement by the genetic study | One year after surgery | Prediction of the postoperative antalgic requirement by the genetic study |
| Effect of remifentanil on skin conductance | One hour after anesthesia | Skin conductance is measured before and after a calibrated noxious stimulus. This test is performed after the induction of anesthesia (propofol) and a first time before remifentanil administration and a second time after. |
Countries
France
Outcome results
None listed