Pain
Conditions
Keywords
Cannabis, THC, Pain
Brief summary
The purpose of this study is to test the effects of cannabinoids on pain response using a variety of human experimental pain models.
Interventions
OTHERThermal
Thermal sensation/pain testing
OTHERElectrical
Electrical sensation/pain testing
OTHERCapsaicin
Intradermal Capsaicin
DRUGTHC
Active THC (0.01 mg/kg) administered over 10 minutes
DRUGPlacebo
Control: small amount of alcohol with no THC, administered over 10 minutes
Sponsors
Yale University
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
HEALTH_SERVICES_RESEARCH
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 55 Years
Healthy volunteers
Yes
Inclusion criteria
* At least one lifetime exposure to cannabis * Acceptable Birth Control methods for females
Exclusion criteria
* Cannabis naive * Medical or psychiatric contraindications * Analgesic medication * Previous sensitivity to THC or cannabis
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Capsaicin-induced hyperalgesia | On each test day at baseline (-30), peak (+20) and post (+120) drug administration |
Secondary
| Measure | Time frame |
|---|---|
| Non-pain subjective responses | On each test day at baseline (-30), peak (+20) and post (+120) drug administration |
| Pain Measures | On each test day at baseline (-30), peak (+20) and post (+120) drug administration |
| Cognitive subjective responses | On each test day at baseline (-30), peak (+20) and post (+120) drug administration |
Countries
United States
Outcome results
None listed