Local Metabolic Effects of Ghrelin in Skeletal Muscle and Adipose Tissue

Local Metabolic Effects of Ghrelin: A Clinical Microdialysis Study

Status

Completed

Phases

Early Phase 1

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01595373

Enrollment

Registered

2012-05-10

Start date

2012-06-30

Completion date

2013-01-31

Last updated

2013-01-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Healthy

Keywords

Ghrelin, Microdialysis, Controls, Metabolic effects of ghrelin

Brief summary

The metabolic effects of ghrelin is investigated by microdialysis technique. Subjects are healthy young men. End points are interstitial concentrations of glucose, lactate, and glycerol.

Interventions

DRUGAcyl ghrelin

Acyl ghrelin 12.5 pg/min infused continuously for 300 minutes

DRUGPlacebo (Ringer acetate)

Ringer acetate 2 microliter/min for 300 minutes

Study design

Allocation

RANDOMIZED

Intervention model

CROSSOVER

Primary purpose

BASIC_SCIENCE

Masking

SINGLE (Subject)

Eligibility

Sex/Gender

MALE

Age

18 Years to 65 Years

Healthy volunteers

Yes

Inclusion criteria

* healthy male * age 18-65 years (included) * Body mass index 20-25 (included)

Exclusion criteria

* alcohol abuse * malignant disease * use of any medicine except otc painkillers * any disease recognized * participation in a trial using radioactive isotopes within the last 6 months

Design outcomes

Primary

Measure	Time frame
Interstitial concentrations of glycerol	Interstitial concentrations of glycerol at t=120 minutes

Secondary

Measure	Time frame
Interstitial concentrations of lactate	Interstitial concentrations of lactate at t=120 minutes
Interstitial concentrations of glucose	Interstitial concentrations of glucose at t=120 minutes

Countries

Denmark

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026