Diabetes Mellitus Type 2
Conditions
Brief summary
A comparison of two treatment approaches for hyperglycemia in diabetic patients hospitalized in the medical department. The first approach is called basal-bolus in which 4 insulin shots are given daily ( 3 short acting before meals and one long acting before bed time). The second approach is called sliding scale in which short acting insulin alone is given before meals and before bed time according to the patient's glucose values. The aim is to keep fasting glucose between 140-180 mg/dl.
Interventions
DRUGInsulin, regular - act rapid
4 shots of regular insulin: 3 before meals and one at bedtime.
DRUGInsulin glulisine, Insulin glargine
1 shot glargine at bedtime 3 shots glulisine before meals
Sponsors
HaEmek Medical Center, Israel
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 100 Years
Healthy volunteers
No
Inclusion criteria
* Patients admitted to internal medicine ward with blood glucose (BG) between 140-400 mg/dl. * Known history (\>6months) of diabetes. * Aged 18-80 years old. * Previous therapy including either diet alone or any combination of oral hypoglycemia agents, glucagon-like peptide 1 (GLP-1) analogs and long acting insulin analogs or Neutral Protamine Hagedorn (NPH).
Exclusion criteria
* Pregnancy * Patients with ketoacidosis * Patients with unknown history of diabetes * Patients with type 1 diabetes mellitus * Patients with clinically relevant hepatic disease or renal impairment ( serum creatinine≥2.5 mg/dl) * Use of corticosteroid therapy * Patient with any mental disorder preventing him to cooperate and give informed consent. * Patients on multiple daily doses of insulin regimen.
Outcome results
None listed