Hemoperitoneum
Conditions
Brief summary
Our objective is to determine whether or not the presence of hemoperitoneum in trauma patients is associated with increased Carbon Monoxide (CO) formation, and to determine if elevated Carbon Monoxide levels are associated with cardiovascular depression, impaired platelet aggregation, and/or multiple organ failure.
Interventions
PROCEDUREexpired air
collection of expired air from ventilator
Sponsors
The University of Texas Health Science Center at San Antonio
Study design
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
1. Hospitalized males 18 years of age or older, 2. Diagnosis of isolated blunt OR blunt and penetrating trauma, 3. Admitted or expecting to be admitted to the Intensive Care Unit, 4. On mechanical ventilation, and 5. Written informed consent obtained
Exclusion criteria
1. Female gender, (Females will be excluded from this study as the menstrual cycle and other estrogen variations are known to be associated with cyclic changes in CO production adding a potential confounder to the interpretations of our findings.) 2. Diagnosis of isolated penetrating trauma, 3. Acute hemothorax or pneumothorax, 4. Treatment with antiaggregants (ASA, clopidogrel, aggrenox or ticlopidine), 5. Enrollment in another research study, 6. Prisoners, 7. Inability to perform CO measurement within 96 hours after hospital admission.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| •Establish a method for reliably measuring CO excretion in patients. | 96 hours |
Countries
United States
Outcome results
None listed