Acute Effects of Exercise in Women With Fibromyalgia (FM)

Acute Effects of Exercise in Women With FM

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT01592916

Enrollment

Registered

2012-05-07

Start date

2012-05-10

Completion date

2012-11-23

Last updated

2018-02-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Fibromyalgia

Keywords

Fibromyalgia, Pain, Women, Exercise, IGF1

Brief summary

The investigators previous studies of aerobic exercise in women with fibromyalgia (FM) have shown that exercise improves body functions and/or symptom severity in most patients, but not in all. About a third of patients with FM have been shown to have low levels of IGF-1. The purpose of this project is to study individual and biological factors that interact with outcomes of short-term (acute) exercise in FM. Method. A controlled prospective exercise study. Thirty women with FM and 30 healthy age-matched women, aged 20-50 years, will be recruited to the study. Two 15-minute ergometer bicycle exercise tests will be conducted in feasting patients, separated by one month. The first exercise test is at a low and the second at a high intensity. Measurements comprise blood test, pain rating and pain threshold, conducted before and after the test. The levels of IGF-1, IL-6 and IL-8 will be measured, and the changes in them will be related to health status and pain.

Interventions

None listed

Study design

Observational model

CASE_CONTROL

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

FEMALE

Age

20 Years to 50 Years

Healthy volunteers

Yes

Inclusion criteria

* clinical diagnosis of fibromyalgia * age 20-50 years

Exclusion criteria

* heart disease * neurological disease * severe osteoarthritis

Design outcomes

Primary

Measure	Time frame	Description
IGF1 level	15 min	Ergometer cycle test of 15 minutes at low respective high intensity. Blood test is done before and after exercise. Change in quantity of IGF1 is measured.

Secondary

Measure	Time frame	Description
Pain rating	15 minutes	Pain is rated by the test person before and after the ergometer cycle test.
Pain threshold	15 minutes	Pain threshold is measured before and after the ergometer test.
Interleukin 6 and 8	15 minutes	Blood test is done before and after the ergometer bicycle test. Quantity of interleukin 6 and 8 is measured.

Countries

Sweden

Outcome results