Laryngeal Injuries
Conditions
Keywords
laryngeal injuries, vocal cord injuries, hoarseness, sore throat
Brief summary
Anesthesia induction with sevoflurane is not associated with an increased incidence or severity of laryngeal injuries compared with an anesthesia induction with a muscle relaxant.
Interventions
DRUGSevoflurane
anesthesia induction with propofol, remifentanil and sevoflurane; afterwards tracheal intubation
DRUGRocuronium
anesthesia induction with propofol, remifentanil and rocuronium; afterwards tracheal intubation
Sponsors
University of Rostock
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
TRIPLE (Subject, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
* ear-nose-throat surgery * orotracheal intubation for surgery of the ear
Exclusion criteria
* obesity * allergy against the study drugs * patients with a known or suspected difficult airway (Mallampati score 3 or 4 and a mouth opening \< 3.5 cm). * all patients were examined by stroboscopy one day before surgery and were excluded from the study when preexisting pathologies of the vocal cords were found
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| incidence of vocal cord injuries | 24 h after tracheal intubation |
Secondary
| Measure | Time frame |
|---|---|
| incidence of hoarseness | 24h, 48 h, and 72 h after tracheal intubation |
| incidence of soar throat | 24h, 48h, and 72 h after tracheal intubation |
Countries
Germany
Outcome results
None listed