Brain Activation in Response to Appetitive Cues Pre- and Post- Bariatric Surgery

Brain Activation in Response to Appetite Cues Pre- and Post- Bariatric Surgery

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01590914

Enrollment

120

Registered

2012-05-03

Start date

2008-01-31

Completion date

2014-01-31

Last updated

2024-08-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Obesity

Keywords

Roux-en-Y Bariatric surgery,, Gastric banding,, fMRI,, food cues

Brief summary

Utilizing fMRI, this study will examine changes in BOLD signal as a proxy measure of brain activation in response to highly palatable (high energy density \[kcal/g\]), less palatable and non-food stimuli in severely obese women pre, 1 month post and 3 months post undergoing bariatric surgery (in surgery patients) and at equivalent times for control groups in fed and fasted conditions at each time point. Two surgical groups: (i) laparoscopic Roux-en-Y gastric bypass (RYGB) and (ii) gastric banding (GB) will be compared with two control groups: (i)those enrolled on a 3-month formula weight loss program or (ii) those who qualify, but do not undergo bariatric surgery, and receive no weight loss treatment.

Interventions

PROCEDUREFed Condition

Subjects will consume a 250ml liquid test meal (250kcal) before undergoing a 40min fMRI scan to assess the BOLD signal responses to visual and auditory responses to food and non-food cues.

PROCEDUREFasted Condition

Subjects will consume a 250ml control (water) before undergoing a 40min fMRI scan to assess BOLD signal response to visual and auditory food and non-food cues

Study design

Allocation

NON_RANDOMIZED

Intervention model

CROSSOVER

Primary purpose

BASIC_SCIENCE

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to 65 Years

Healthy volunteers

Yes

Inclusion criteria

* Age \> 18 and \< 65 years * BMI \> 40 and \< 50kg/m2 * Right handed * Good comprehension of English

Exclusion criteria

* \> 5% weight fluctuation in the past 3 months * Presence of disease (including diabetes) * Pregnancy, lactation or planning to become pregnant in next 18mon * Smoking, or or recent (within past 12 month) smoking cessation * Consumption of \> 3 alcoholic beverages per day * Left handed

Design outcomes

Primary

Measure	Time frame	Description
BOLD signal response to visual and auditory food cues	pre-surgery, 1mo post and 3mo post surgery	BOLD signal changes in the brain in response to highly palatable (high energy density \[kcal/g\]), less palatable (low energy density)and non-food, stimuli in severely obese women pre-surgery, 1 month post-surgery and 3 months post bariatric surgery

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026