Identification the Expression of Sox2 in Colorectal Cancer Tissues

The Role of Sox2 in Tumor Genesis and Migration in Colorectal Cancer

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT01589900

Enrollment

136

Registered

2012-05-02

Start date

2005-01-31

Completion date

2012-03-31

Last updated

2012-05-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Colorectal Cancer

Keywords

colorectal cancer, invasion, metastasis, IHC

Brief summary

Sox2 has been studied in several types of human solid tumors. The investigators found that Sox2 had higher expression level in colorectal cancer and metastatic tissues than normal tissues. So the investigators assumed that whether Sox2 plays an important role in the progression and migration of colon cancer.

Detailed description

In our study, we examined Sox2 expression in archived human colon cancer tissues and found that its Sox2 expression correlates with reduced patient survival, increased tumor grade and metastasis probability.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

24 Years to 79 Years

Healthy volunteers

Inclusion criteria

* Clinical diagnosis of colorectal cancer

Exclusion criteria

* Clinical diagnosis characteristics not exactly described in the patients information

Outcome results