Polycystic Kidney, Autosomal Dominant
Conditions
Keywords
Uric acid, polycystic kidney disease
Brief summary
There are substantial data demonstrating increased endothelial dysfunction, inflammation and oxidative stress in patients with Autosomal dominant polycystic kidney disease (ADPKD), the association between serum uric acid level and endothelial dysfunction has not been elucidated yet in these patients. Therefore, in this study, the investigators aimed to examine the relationship between the uric acid level and the ED in normotensive ADPKD patients with preserved renal function.
Detailed description
This is the first study to evaluate the relationship between uric acid and endothelial dysfunction in patients with early stage ADPKD
Interventions
None listed
Sponsors
TC Erciyes University
Study design
Observational model
COHORT
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
20 Years to 60 Years
Healthy volunteers
No
Inclusion criteria
* ADPKD patients with normal renal function, * Normotensive ADPKD patients
Exclusion criteria
* Patients with impaired kidney function, * Atherosclerotic disorders, * Diagnosis of hypertension, gout, diabetes, * Using of insulin, thiazide, allopurinol or uricosuric drugs
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Measurement of asymmetric dimethylarginine (ADMA) and flow mediated dilatation (FMD) | 4 months | ADMA,FMD and uric acid measurements were performed to determine endothelial dysfunction in ADPKD patients |
Countries
Turkey (Türkiye)
Outcome results
None listed