Dental Caries
Conditions
Keywords
toothpastes, saliva, dental caries, fluoride
Brief summary
Considering the widespread use of sodium fluoride (NaF) and monofluorophosphate (MFP) based toothpastes, the present study aim to evaluate F availability in saliva after use of the top-selling Brazilian toothpastes. In a blind, crossover clinical trial study, volunteers will brush their teeth with one of the following toothpastes: 1) non-fluoride toothpaste (negative control group); 2) NaF/silica based toothpaste 3)MFP/calcium carbonate based toothpaste. After brushing, a rinse with purified water will be performed. Unstimulated saliva will be collected before and up to 60 min after brushing. Ionic fluoride and total soluble fluoride (corresponding to the sum of fluoride as ion and as MFP) will be determined after acid treatment of salivary samples to hydrolyze MFP. Fluoride will be determined using an ion selective electrode.
Interventions
DRUGToothpaste
1-min brushing with 1 g of the assigned toothpaste followed by a 10 mL purified water rinse
Sponsors
University of Campinas, Brazil
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
PREVENTION
Masking
SINGLE (Investigator)
Eligibility
Sex/Gender
ALL
Age
18 Years to 35 Years
Healthy volunteers
Yes
Inclusion criteria
* Good general health * Good oral health * Normal salivary flow rate
Exclusion criteria
* Use of systemic drugs that reduce salivary flow rate
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Area under the curve of salivary fluoride concentration versus time after brushing with fluoride toothpastes | 60 minutes |
Secondary
| Measure | Time frame |
|---|---|
| Percentage of MFP hydrolyzed in saliva as a function of time | 60 minutes |
Countries
Brazil
Outcome results
None listed