Atherosclerosis, Metabolic Syndrome
Conditions
Brief summary
Coronary MDCT (multi-detector computed tomography) has been useful screening imaging modality for the coronary artery disease. Recently, novel adipokines and hepatokines as well as various inflammatory markers have been known as direct regulators of atherosclerosis. Therefore, the investigators examine the correlation of various metabolic risk factors including adipokines and hepatokines with coronary atherosclerosis measured by coronary MDCT in apparently healthy people.
Interventions
None listed
Sponsors
Korea University
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
20 Years to 80 Years
Healthy volunteers
Yes
Inclusion criteria
* Apparently healthy people who underwent medical routine check up in Korea Health Promotion Center. * age \> 20 years
Exclusion criteria
* History of cardiovascular disease (myocardial infarction, unstable angina, stroke, or cardiovascular revascularization) * Diabetes * Stage 2 hypertension * Severe renal or hepatic disease
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| relation of adipokines and hepatokines with coronary atherosclerosis measured by MDCT | 3month | to examine the correlation of serum concentration of various adipokine such as adiponectin, resistin, A-FABP with coronary atheroslcerosis measured by MDCT as AGATSTON score, modified Gensini score |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| relation of adipokines and hepatokines with coronary atherosclerosis measured by MDCT | 3months | to examine the correlation of serum concentration of various hepatokines such as FGF-21, fetuin- A and selenoprotein P with coronary atheroslcerosis measured by MDCT as AGATSTON score, modified Gensini score |
| the correlation of various inflammatory markers with coronary atherosclerosis | 3months | — |
Countries
South Korea
Outcome results
None listed