Lack of Satiety, Excess Intake of Macronutrients, Appetite Disorders
Conditions
Keywords
Satiety, Food intake regulation, Appetite regulation, Dairy Protein
Brief summary
Assessing 5 different milk derived proteins versus placebo for appetite regulation and satiety, delivered via shake vehicle.
Detailed description
Assessing 5 different milk derived proteins versus placebo for appetite regulation and satiety, delivered via shake vehicle. Subjects will attend a 5 hour post-prandial study day. Subjects will keep food records 1 and 3 days prior to study visit, day of visit, and day after visit; food to be weighed using study provided dietary scale.
Interventions
OTHERWhey
Preload containing complete whey protein.
OTHERWhey-CMP
Preload containing complete whey protein which is missing the CMP/GMP portion of the protein.
OTHERControl
Preload control matched for energy to the other 5 preloads.
OTHERCMP
Preload containing the CMP (casinomacropeptide) portion cleaved from complete whey protein.
OTHERMPI
Preload containing whole milk protein.
OTHERCPI
Preload containing sodium caseinate.
Sponsors
University of California, Davis
Study design
Allocation
RANDOMIZED
Intervention model
FACTORIAL
Primary purpose
BASIC_SCIENCE
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 45 Years
Healthy volunteers
Yes
Inclusion criteria
* Healthy * Unrestrained (score ≤ 10 on the Eating Inventory (EI) questionnaire, Stunkard and Messick 1985) * Women * 18 years of age * Consume a low/moderate protein diet (12-20% protein energy). * Meet BMI criteria of 19 to 24 kg/m2 OR 29 to 34 kg/m2, inclusive.
Exclusion criteria
* Women who score ≥ 10 on the Beck Depression Inventory (BDI, Beck and Beamesdorfer 1974) * Women who score ≥ 30 on Eating Attitudes Test (EAT, Garner and Garfinkel 1979), * Have current or past (previous 1 year) medical conditions that may interfere with any of the outcomes of this study. * Weigh less than 110 lbs * Are currently or have been modifying diet or exercise patterns to gain or lose weight in previous 60 days * Have unstable body weight (fluctuations of ≥ 5 kg in 60 day period) * Are excessive exercisers or trained athletes * Taking any medications that would affect appetite or any other study-described endpoint will also be excluded. * Allergies or intolerances to foods consumed in the study. * Smoker * Pregnant/lactation
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Post-prandial satiety | 6 hours | Blood biochemical markers of appetite regulation. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Extended satiety | 48 hours | Utilizing self reported food intake, looking for changes associated with the different proetin compositions of the shakes. |
Countries
United States
Outcome results
None listed