Anemia
Conditions
Keywords
Anemia, Transfusion, RBC storage age, Tissue oxygenation, Malaria
Brief summary
The hypothesis of this study is that prolonged-storage RBCs are not inferior to short-storage RBCs for the time required to clear elevated blood lactate levels in children with severe anemia.
Detailed description
This study will measure the time to resolution of lactic acidosis in patients with severe anemia following blood transfusion.
Interventions
BIOLOGICALRBC transfusion
RBC transfusion of different storage age
Sponsors
Massachusetts General Hospital
Study design
Allocation
RANDOMIZED
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
6 Months to 5 Years
Healthy volunteers
No
Inclusion criteria
* Age 6 mos to 5 years * Hg \< 5 g/dL and Lactate \> 5 mM
Exclusion criteria
* Receiving transfusion other than RBCs * Children with known or suspected cardiac disease
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Reduction of elevated levels of blood lactate during 24 following RBC transfusion | 24 hours |
Secondary
| Measure | Time frame |
|---|---|
| Normalization of vital signs | 24 hours |
| Correction of acidosis | 24 hours |
Countries
Uganda
Outcome results
None listed