Cancer, Non Small Cell Lung Cancer
Conditions
Keywords
Phase I, Drug evaluation, Oncology, Vandetanib, Selumetinib, Dose escalation, Clinical trial, Vascular Endothelial Growth Factor (VEGFR) inhibitor, Epidermal Growth Factor Receptor (EGFR) inhibitor, Mitogen Activated Kinase (MEK) inhibitor, Non small cell lung cancer
Brief summary
The purpose of this study is to determine whether using two drugs together called vandetanib and selumetinib is effective in the treatment of cancer. The first part of this study will include patients with any solid tumour and the second part of this study will include only patients with non small cell lung cancer. The four main aims of this clinical study are to find out: * If the two drugs can be given safely to patients when given together. * The maximum dose that can be given safely to patients. * More about the potential side effects of the drugs and how they can be managed. * What happens to vandetanib and selumetinib inside the body.
Detailed description
The purpose of this Phase I study is to establish a safety and toxicity profile of combining two study drugs; vandetanib, a VEGFR (Vascular Endothelial Growth Factor Receptor) and EGFR (Epidermal Growth Factor Receptor) inhibitor, with selumetinib a MEK (Mitogen Activated Kinase) inhibitor. This is the first time the drugs have been used together. These types of drugs have shown an effect in non small cell lung cancer (NSCLC). The study is in two parts; the dose escalation phase and the expansion phase. In the dose escalation phase, 42-50 patients will receive different doses of vandetanib and increasing doses of selumetinib to establish a safe dose to recommend for the next stage of the study. Patients with any solid tumour will be eligible. In the expansion phase, up to 30 patients will receive the dose recommended in the previous phase. Only patients with NSCLC will be eligible for this part of the study. The expansion phase will look at further evaluating the safety of the drug combination and the anti-tumour activity. Patients in this cohort will be requested to also consent to have additional imaging assessments and optional tumour biopsies. Study treatment is administered orally; vandetanib tablets once daily and selumetinib capsules once daily (OD)/twice daily (BD). Cycle 1 is 42 days long. Subsequent cycles are 28 days in length. Patients will receive a total of 6 cycles of the combination treatment. If the patient has not progressed after six cycles, they may be treated for further cycles following approval from the sponsor.
Interventions
DRUGVandetanib, Selumetinib
Cycle 1: Vandetanib higher (lead in) dose of 300 mg OD (Days 1 to 4) followed by vandetanib steady state dose of 100 mg OD (Days 5 to 14) followed by vandetanib steady state dose of 100 mg OD + 25 mg of selumetinib BD (28 days). Cycle 1 is 42 days long. Cycle 2 onwards: Vandetanib steady state dose of 100 mg OD + 25 mg of selumetinib BD (28 days). From Cycle 2, cycles are 28 days long. Patients will be allowed to receive 6 cycles. If the patient is still benefiting clinically with no unacceptable toxicity, then the Investigator can ask the Sponsor for continuation of treatment.
Sponsors
AstraZeneca
Cancer Research UK
Study design
Allocation
NON_RANDOMIZED
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
1. (Dose escalation cohorts) Histologically or cytologically proven solid tumour for which no conventional therapy exists or is declined by the patient 2. (Expansion cohort only) Histologically or cytologically confirmed NSCLC patients only, for which no conventional therapy exists or is declined by the patient. * If only cytologically confirmed, baseline biopsy is mandatory for a patient to be eligible. * For NSCLC patients to be eligible for the expansion cohort they must have received: * One prior line of chemotherapy and/or * Previous platinum based chemotherapy and/or * At least one previous EGFR inhibitor 3. (Expansion cohort only) Measurable disease according to RECIST criteria Version 1.1 in final version of the protocol 4. Life expectancy of at least 12 weeks 5. World Health Organisation (WHO) performance status of 0-1 6. Baseline LVEF \> 50% 7. Haematological and biochemical indices within the ranges shown below. These measurements must be performed within one week (Day -7 to Day -1) before the patient goes on study. Laboratory Test Value required Haemoglobin (Hb) ≥ 9.0 g/dL Absolute neutrophil count ≥ 1.5 x 10\^9/L Platelet count ≥ 100 x 10\^9 /L Normal serum calcium (adjusted)\* 2.15-2.55 mmol/L Normal serum magnesium\* 0.60-1.0 mmol/L Normal serum potassium \>4.0 mmol/L Either: Serum bilirubin ≥1.5 x upper limit of normal (ULN) This does not apply to patients with Gilbert's disease. Alanine amino-transferase (ALT) or aspartate amino-transferase (AST) and alkaline phosphatase (ALP) ≤ 2.5 x ULN unless raised due to liver metastases in which case up to 5 x ULN is permissible Either: Calculated creatinine clearance (using the Wright or C&G formula) \> 50 mL/min Or: Isotope clearance measurement\*\* ≥ 50 mL/min (uncorrected) INR or aPTT \< 1.5 x ULN \*or normal range according to the local laboratory \*\* Isotope clearance result to be used to confirm eligibility if calculated C&G/Wright method results in GFR of = 50 mL/min. \*\*\* Therapeutic INR values (2.0-3.0) are acceptable to confirm eligibility for patients who are taking concomitant warfarin. 8. 18 years or over 9. Ability to swallow and retain oral medications. 10. Written (signed and dated) informed consent and be capable of co-operating with treatment, and follow-up
Exclusion criteria
1. Radiotherapy (except for palliative reasons), endocrine therapy, immunotherapy or chemotherapy during the previous 4 weeks (6 weeks for investigational medicinal products) before treatment. 2. Patients who have been withdrawn from treatment with agents that target EGFR because of unacceptable toxicity (prior treatment with these agents is allowed) and those patients who have had EGFR dose reductions by 50% or more. 3. Expansion cohort only: Prior treatment with any agent that targets MEK or VEGFR 4. Any prior exposure to RAS or RAF inhibitors 5. Ongoing toxic manifestations of previous treatments. Exceptions to this are alopecia or certain Grade 2 toxicities, which in the opinion of the Investigator and the Centre for Drug Development (CDD) should not exclude the patient. 6. Symptomatic brain metastases (patients must be stable for \>3 months post RT treatment) or spinal cord compression. 7. Patients with interstitial lung disease. 8. Pregnant or lactating women are excluded. Female patients with the ability to become pregnant who have a negative serum or urine pregnancy test before enrollment and agree to use two of the following three highly effective forms of combined contraception (oral, injected or implanted hormonal contraception and condom, have a intra-uterine device and condom, diaphragm with spermicidal gel and condom) for four weeks before entering the trial, during the trial and for six months afterwards are considered eligible. 9. Male patients with partners of child-bearing potential (unless they agree to take measures not to father children by using one form of highly effective contraception \[condom plus spermicide\] during the trial and for six months afterwards). Men with pregnant or lactating partners should be advised to use barrier method contraception (e.g. condom plus spermicidal gel) to prevent exposure to the foetus or neonate. 10. Major surgery from which the patient has not yet recovered. 11. At high medical risk because of non-malignant systemic disease including active uncontrolled infection. 12. Known to be serologically positive for Hepatitis B, Hepatitis C or Human Immunodeficiency Virus (HIV). 13. Cardiac conditions as follows: * Clinically significant cardiovascular event within 3 months prior to entry to include: * Myocardial infarction * Angina requiring use of nitrates more than once weekly * Superior vena cava syndrome * Class II/III/IV cardiac disease (New York Heart Association \[NYHA\]) * Presence of cardiac disease that in the opinion of the Investigator increases the risk of ventricular arrhythmia. * History of arrhythmia which is symptomatic or requires treatment (CTCAE V4.02), symptomatic or uncontrolled atrial fibrillation despite treatment or asymptomatic sustained ventricular tachycardia. Patients with atrial fibrillation controlled by medication are permitted. * Uncontrolled hypertension (BP \> 160/100 despite optimal therapy) * Prior or current cardiomyopathy * Atrial fibrillation with heart rate \> 100 bpm * QTcB \> or equal to 450 msec on screening ECG (Note: If a patient has a QTcB interval \> or equal to 450 msec on screening ECG, the screen ECG may be repeated twice \[at least 24 hours apart\]. The average QTcB from the three screening ECGs must be \< 450 msec in order for the subject to be eligible for the study.) * History of congenital long QT syndrome * History of Torsade de Pointes (or any concurrent medication with a known risk of inducing Torsades de Pointes.) 14. Concomitant medications that are potent inducers of CYP3A4 function i.e. rifampicin, rifabutin, phenytoin, carbamazepine, Phenobarbital and St Johns Wort. 15. Any other condition which in the Investigators opinion would not make the patient a good candidate for the clinical trial (e.g. evidence of severe or uncontrolled systemic disease or concurrent condition or that may affect ability to absorb oral agents). 16. Current malignancies of other types, with the exception of adequately treated cone-biopsied in situ carcinoma of the cervix uteri and basal or squamous cell carcinoma of the skin. Cancer survivors, who have undergone potentially curative therapy for a prior malignancy, have no evidence of that disease for five years or more and are deemed at negligible risk for recurrence, are eligible for the trial. 17. If a participant plans to participate in another interventional clinical study, whilst taking part in this Phase I study. Participation in an observational study would be acceptable. 18. Ophthalmological conditions as follows: 1. Current or past history of retinal pigment epithelial detachment (RPED)/central serous retinopathy (CSR) or retinal vein occlusion. 2. Intraocular pressure (IOP) \> 21 mmHg or uncontrolled glaucoma (irrespective of IOP).
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Number of Serious Adverse Events, Non-serious Adverse Events and Treatment Emergent Adverse Events. | Safety data was collected from the date of written informed consent and continued until 28 days after the final administration of vandetanib and selumetinib, an average (mean) of 164 days (approximately 5.4 months). | Number of serious adverse events, non-serious adverse events and treatment emergent adverse events. |
| Number of Dose Limiting Toxicities (DLTs) Within Each Cohort. | DLTs occurring in the first Cycle (up to Day 42). | Number of DLTs within each cohort. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Dose Escalation Cohorts Only: PK Parameter Area Under the Plasma Concentration Time Curve (0-24 Hours) of Vandetanib. | 0 hours (pre dose) and at 0.5, 2, 4, 6 and 24 hours post dose on Day 4. 0 hours (pre dose) and at 0.5, 2, 4, 6, 10 and 24 hours post dose on Days 15 and 29. | Area under the plasma concentration time curve (0-24 hours) of vandetanib post treatment with vandetanib alone and following the combination of vandetanib and selumetinib. |
| Dose Escalation Cohorts Only: PK Parameter Area Under the Plasma Concentration Time Curve (0-12 Hours) of Selumetinib. | 0 hours (pre dose) and at 0.5, 2, 4, 6 and 10 hours post dose on Days 15 and 29. | Area under the plasma concentration time curve (0-12 hours) of selumetinib post treatment with the combination of vandetanib and selumetinib. This was extrapolated from the sampling data up to 10 hours to allow comparison with literature data. |
| Dose Escalation Cohorts Only: PK Parameter Area Under the Plasma Concentration Time Curve (0-12 Hours) of N-desmethyl Metabolite of Selumetinib. | 0 hours (pre dose) and at 0.5, 2, 4, 6 and 10 hours post dose on Days 15 and 29. | Area under the plasma concentration time curve (0-12 hours) of N-desmethyl metabolite of selumetinib following the combination of vandetanib and selumetinib. This was extrapolated from the sampling data up to 10 hours to allow comparison with literature data. |
| Dose Escalation Cohorts Only: PK Parameter Maximum Observed Plasma Concentration of Vandetanib. | 0 hours (pre dose) and at 0.5, 2, 4, 6 and 24 hours post dose on Day 4. 0 hours (pre dose) and at 0.5, 2, 4, 6, 10 and 24 hours post dose on Days 15 and 29. | Maximum observed plasma concentration of vandetanib post treatment with vandetanib alone and following the combination of vandetanib and selumetinib. |
| Expansion Cohort Only: One Year Survival of Patients With NSCLC After Treatment With the Combination of Vandetanib and Selumetinib. | 1 year from date of first dose of vandetanib. | Number of patients alive at one year. |
| Expansion Cohort Only: Tumour Metabolism in Patients With NSCLC Using Positron Emission Tomography Response Criteria in Solid Tumours (PERCIST) Criteria. | Baseline, Day 12, Day 42. | Tumour metabolism using 18F-fluorodeoxyglucose positron emission tomography (\[18F\]FDG-PET) computerised tomography (CT) imaging pre and post treatment with vandetanib alone and following the combination of vandetanib and selumetinib. These were assessed and reported according to PERCIST criteria. |
| Expansion Cohort Only: Progression Free Survival (PFS) of Patients With NSCLC After Treatment With the Combination of Vandetanib and Selumetinib. | 10 and 18 weeks from date of first dose of vandetanib. | PFS by Response Evaluation Criteria in Solid Tumours Criteria (RECIST v1.0). Per RECIST for target lesions and assessed by computerised tomography (CT), progressive disease was defined as at least a 20% increase in the sum of diameters of target lesions, taking as reference the smallest sum while on trial, or the appearance of one or more new lesions. |
| Dose Escalation Cohorts Only: PK Parameter Maximum Observed Plasma Concentration of Selumetinib. | 0 hours (pre dose) and at 0.5, 2, 4, 6, 10 and 24 hours post dose on Days 15 and 29. | Maximum observed plasma concentration of selumetinib post treatment with the combination of vandetanib and selumetinib. |
Countries
United Kingdom
Participant flow
Recruitment details
Trial participants were enrolled at three trial sites between 10 January 2012 and 19 September 2017.
Participants by arm
| Arm | Count |
|---|---|
| Dose Escalation Phase Cohort 1 (Steady State Dose of 100 mg OD Vandetanib + 25 mg BD Selumetinib) Dose escalation to determine the recommended dose and schedule for Phase 2 evaluation of vandetanib and selumetinib.
Cycle 1: Vandetanib higher (lead in) dose of 300 mg OD (Days 1 to 4) followed by vandetanib steady state dose of 100 mg OD (Days 5 to 14) followed by vandetanib steady state dose of 100 mg OD + 25 mg of selumetinib BD (28 days). Cycle 1 is 42 days long.
Cycle 2 onwards: Vandetanib steady state dose of 100 mg OD + 25 mg of selumetinib BD (28 days). From Cycle 2, cycles are 28 days long.
Patients will be allowed to receive 6 cycles. If the patient is still benefiting clinically with no unacceptable toxicity, then the Investigator can ask the Sponsor for continuation of treatment. | 6 |
| Dose Escalation Phase Cohort 2 (Steady State Dose of 100 mg OD Vandetanib + 50 mg BD Selumetinib ) Dose escalation to determine the recommended dose and schedule for Phase 2 evaluation of vandetanib and selumetinib.
Cycle 1: Vandetanib higher (lead in) dose of 300 mg OD (Days 1 to 4) followed by vandetanib steady state dose of 100 mg OD (Days 5 to 14) followed by vandetanib steady state dose of 100 mg OD + 50 mg of selumetinib BD (28 days). Cycle 1 is 42 days long.
Cycle 2 onwards: Vandetanib steady state dose of 100 mg OD + 50 mg of selumetinib BD (28 days). From Cycle 2, cycles are 28 days long.
Patients will be allowed to receive 6 cycles. If the patient is still benefiting clinically with no unacceptable toxicity, then the Investigator can ask the Sponsor for continuation of treatment. | 6 |
| Dose Escalation Phase Cohort 3 (Steady State Dose of 100 mg OD Vandetanib + 75 mg BD Selumetinib ) Dose escalation to determine the recommended dose and schedule for Phase 2 evaluation of vandetanib and selumetinib.
Cycle 1: Vandetanib higher (lead in) dose of 300 mg OD (Days 1 to 4) followed by vandetanib steady state dose of 100 mg OD (Days 5 to 14) followed by vandetanib steady state dose of 100 mg OD + 75 mg of selumetinib BD (28 days). Cycle 1 is 42 days long.
Cycle 2 onwards: Vandetanib steady state dose of 100 mg OD + 75 mg of selumetinib BD (28 days). From Cycle 2, cycles are 28 days long.
Patients will be allowed to receive 6 cycles. If the patient is still benefiting clinically with no unacceptable toxicity, then the Investigator can ask the Sponsor for continuation of treatment. | 6 |
| Dose Escalation Phase Cohort 4 (Steady State Dose of 100 mg OD Vandetanib + 100 mg OD Selumetinib) Dose escalation to determine the recommended dose and schedule for Phase 2 evaluation of vandetanib and selumetinib.
Cycle 1: Vandetanib higher (lead in) dose of 300 mg OD (Days 1 to 4) followed by vandetanib steady state dose of 100 mg OD (Days 5 to 14) followed by vandetanib steady state dose of 100 mg OD + 100 mg of selumetinib OD (28 days). Cycle 1 is 42 days long.
Cycle 2 onwards: Vandetanib steady state dose of 100 mg OD + 100 mg of selumetinib OD (28 days). From Cycle 2, cycles are 28 days long.
Patients will be allowed to receive 6 cycles. If the patient is still benefiting clinically with no unacceptable toxicity, then the Investigator can ask the Sponsor for continuation of treatment. | 7 |
| Dose Escalation Phase Cohort 5a (Steady State Dose of 100 mg OD Vandetanib + 125 mg OD Selumetinib) Dose escalation to determine the recommended dose and schedule for Phase 2 evaluation of vandetanib and selumetinib.
Cycle 1: Vandetanib higher (lead in) dose of 300 mg OD (Days 1 to 4) followed by vandetanib steady state dose of 100 mg OD (Days 5 to 14) followed by vandetanib steady state dose of 100 mg OD + 125 mg of selumetinib OD (28 days). Cycle 1 is 42 days long.
Cycle 2 onwards: Vandetanib steady state dose of 100 mg OD + 125 mg of selumetinib OD (28 days). From Cycle 2, cycles are 28 days long.
Patients will be allowed to receive 6 cycles. If the patient is still benefiting clinically with no unacceptable toxicity, then the Investigator can ask the Sponsor for continuation of treatment. | 9 |
| Dose Escalation Phase Cohort 5b (Steady State Dose of 200 mg OD Vandetanib + 50 mg BD Selumetinib) Dose escalation to determine the recommended dose and schedule for Phase 2 evaluation of vandetanib and selumetinib.
Cycle 1: Vandetanib higher (lead in) dose of 300 mg OD (Days 1 to 4) followed by vandetanib steady state dose of 200 mg OD (Days 5 to 14) followed by vandetanib steady state dose of 200 mg OD + 50 mg of selumetinib BD (28 days). Cycle 1 is 42 days long.
Cycle 2 onwards: Vandetanib steady state dose of 200 mg OD + 50 mg of selumetinib BD (28 days). From Cycle 2, cycles are 28 days long.
Patients will be allowed to receive 6 cycles. If the patient is still benefiting clinically with no unacceptable toxicity, then the Investigator can ask the Sponsor for continuation of treatment. | 8 |
| Dose Escalation Phase Cohort 6 (Steady State Dose of 300 mg OD Vandetanib + 50 mg BD Selumetinib) Dose escalation to determine the recommended dose and schedule for Phase 2 evaluation of vandetanib and selumetinib.
Cycle 1: Vandetanib higher (lead in) dose of 300 mg OD (Days 1 to 2) followed by vandetanib steady state dose of 300 mg OD (Days 3 to 14) followed by vandetanib steady state dose of 300 mg OD + 50 mg of selumetinib BD (28 days). Cycle 1 is 42 days long.
Cycle 2 onwards: Vandetanib steady state dose of 300 mg OD + 50 mg of selumetinib BD (28 days). From Cycle 2, cycles are 28 days long.
Patients will be allowed to receive 6 cycles. If the patient is still benefiting clinically with no unacceptable toxicity, then the Investigator can ask the Sponsor for continuation of treatment. | 8 |
| Expansion Phase (Steady State Dose of 200 mg OD Vandetanib + 50 mg BD Selumetinib) Expansion cohort at the recommended phase 2 dose of vandetanib and selumetinib defined in the escalation phase.
Cycle 1: Vandetanib higher (lead in) dose of 300 mg OD (Days 1 to 4) followed by vandetanib steady state dose of 200 mg OD (Days 5 to 14) followed by vandetanib steady state dose of 200 mg OD + 50 mg of selumetinib BD (28 days). Cycle 1 is 42 days long.
Cycle 2 onwards: Vandetanib steady state dose of 200 mg OD + 50 mg of selumetinib BD (28 days). From Cycle 2, cycles are 28 days long.
Patients will be allowed to receive 6 cycles. If the patient is still benefiting clinically with no unacceptable toxicity, then the Investigator can ask the Sponsor for continuation of treatment. | 11 |
| Total | 61 |
Withdrawals & dropouts
| Period | Reason | FG000 | FG001 | FG002 | FG003 | FG004 | FG005 | FG006 | FG007 |
|---|---|---|---|---|---|---|---|---|---|
| Overall Study | Adverse Event | 3 | 0 | 2 | 1 | 3 | 3 | 2 | 3 |
| Overall Study | Evidence of disease progression | 1 | 3 | 2 | 5 | 3 | 5 | 4 | 6 |
| Overall Study | Physician Decision | 0 | 1 | 1 | 0 | 2 | 0 | 1 | 1 |
| Overall Study | Screen failure (no treatment received) | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
| Overall Study | Withdrawal by Subject | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Baseline characteristics
| Characteristic | Total | Dose Escalation Phase Cohort 2 (Steady State Dose of 100 mg OD Vandetanib + 50 mg BD Selumetinib ) | Dose Escalation Phase Cohort 3 (Steady State Dose of 100 mg OD Vandetanib + 75 mg BD Selumetinib ) | Dose Escalation Phase Cohort 4 (Steady State Dose of 100 mg OD Vandetanib + 100 mg OD Selumetinib) | Dose Escalation Phase Cohort 5a (Steady State Dose of 100 mg OD Vandetanib + 125 mg OD Selumetinib) | Dose Escalation Phase Cohort 5b (Steady State Dose of 200 mg OD Vandetanib + 50 mg BD Selumetinib) | Dose Escalation Phase Cohort 1 (Steady State Dose of 100 mg OD Vandetanib + 25 mg BD Selumetinib) | Dose Escalation Phase Cohort 6 (Steady State Dose of 300 mg OD Vandetanib + 50 mg BD Selumetinib) | Expansion Phase (Steady State Dose of 200 mg OD Vandetanib + 50 mg BD Selumetinib) |
|---|---|---|---|---|---|---|---|---|---|
| Age, Categorical <=18 years | 0 Participants | 0 Participants | 0 Participants | 0 Participants | 0 Participants | 0 Participants | 0 Participants | 0 Participants | 0 Participants |
| Age, Categorical >=65 years | 32 Participants | 1 Participants | 3 Participants | 2 Participants | 6 Participants | 5 Participants | 6 Participants | 4 Participants | 5 Participants |
| Age, Categorical Between 18 and 65 years | 29 Participants | 5 Participants | 3 Participants | 5 Participants | 3 Participants | 3 Participants | 0 Participants | 4 Participants | 6 Participants |
| Race and Ethnicity Not Collected | 0 Participants | — | — | — | — | — | — | — | — |
| Region of Enrollment United Kingdom | 61 participants | 6 participants | 6 participants | 7 participants | 9 participants | 8 participants | 6 participants | 8 participants | 11 participants |
| Sex: Female, Male Female | 31 Participants | 2 Participants | 4 Participants | 4 Participants | 2 Participants | 6 Participants | 3 Participants | 4 Participants | 6 Participants |
| Sex: Female, Male Male | 30 Participants | 4 Participants | 2 Participants | 3 Participants | 7 Participants | 2 Participants | 3 Participants | 4 Participants | 5 Participants |
Adverse events
| Event type | EG000 affected / at risk | EG001 affected / at risk | EG002 affected / at risk | EG003 affected / at risk | EG004 affected / at risk | EG005 affected / at risk | EG006 affected / at risk | EG007 affected / at risk |
|---|---|---|---|---|---|---|---|---|
| deaths Total, all-cause mortality | 0 / 6 | 1 / 6 | 2 / 6 | 0 / 7 | 1 / 8 | 0 / 7 | 1 / 6 | 7 / 11 |
| other Total, other adverse events | 6 / 6 | 6 / 6 | 6 / 6 | 7 / 7 | 8 / 8 | 7 / 7 | 6 / 6 | 11 / 11 |
| serious Total, serious adverse events | 4 / 6 | 4 / 6 | 6 / 6 | 2 / 7 | 7 / 8 | 5 / 7 | 6 / 6 | 8 / 11 |
Outcome results
Primary
Number of Dose Limiting Toxicities (DLTs) Within Each Cohort.
Number of DLTs within each cohort.
Time frame: DLTs occurring in the first Cycle (up to Day 42).
Population: All patients who met the eligibility criteria and received at least one dose of the combination treatment (vandetanib and selumetinib) were evaluable for safety assessment (N=57).
| Arm | Measure | Value (NUMBER) |
|---|---|---|
| Dose Escalation Phase Cohort 1 (Steady State Dose of 100 mg OD Vandetanib + 25 mg BD Selumetinib) | Number of Dose Limiting Toxicities (DLTs) Within Each Cohort. | 1 DLTs |
| Dose Escalation Phase Cohort 2 (Steady State Dose of 100 mg OD Vandetanib + 50 mg BD Selumetinib) | Number of Dose Limiting Toxicities (DLTs) Within Each Cohort. | 0 DLTs |
| Dose Escalation Phase Cohort 3 (Steady State Dose of 100 mg OD Vandetanib + 75 mg BD Selumetinib) | Number of Dose Limiting Toxicities (DLTs) Within Each Cohort. | 1 DLTs |
| Dose Escalation Phase Cohort 4 (Steady State Dose of 100 mg OD Vandetanib + 100 mg OD Selumetinib) | Number of Dose Limiting Toxicities (DLTs) Within Each Cohort. | 1 DLTs |
| Dose Escalation Phase Cohort 5a (Steady State Dose of 100 mg OD Vandetanib + 125 mg OD Selumetinib) | Number of Dose Limiting Toxicities (DLTs) Within Each Cohort. | 2 DLTs |
| Dose Escalation Phase Cohort 5b (Steady State Dose of 200 mg OD Vandetanib + 50 mg BD Selumetinib) | Number of Dose Limiting Toxicities (DLTs) Within Each Cohort. | 1 DLTs |
| Dose Escalation Phase Cohort 6 (Steady State Dose of 300 mg OD Vandetanib + 50 mg BD Selumetinib) | Number of Dose Limiting Toxicities (DLTs) Within Each Cohort. | 1 DLTs |
| Expansion Phase (Steady State Dose of 200 mg OD Vandetanib + 50 mg BD Selumetinib) | Number of Dose Limiting Toxicities (DLTs) Within Each Cohort. | 2 DLTs |
Primary
Number of Serious Adverse Events, Non-serious Adverse Events and Treatment Emergent Adverse Events.
Number of serious adverse events, non-serious adverse events and treatment emergent adverse events.
Time frame: Safety data was collected from the date of written informed consent and continued until 28 days after the final administration of vandetanib and selumetinib, an average (mean) of 164 days (approximately 5.4 months).
Population: All patients who met the eligibility criteria and received at least one dose of the combination treatment (vandetanib and selumetinib) were evaluable for safety assessment (N=57).
| Arm | Measure | Group | Value (NUMBER) |
|---|---|---|---|
| Dose Escalation Phase Cohort 1 (Steady State Dose of 100 mg OD Vandetanib + 25 mg BD Selumetinib) | Number of Serious Adverse Events, Non-serious Adverse Events and Treatment Emergent Adverse Events. | Total SAEs | 10 Adverse events |
| Dose Escalation Phase Cohort 1 (Steady State Dose of 100 mg OD Vandetanib + 25 mg BD Selumetinib) | Number of Serious Adverse Events, Non-serious Adverse Events and Treatment Emergent Adverse Events. | Total treatment emergent AEs | 107 Adverse events |
| Dose Escalation Phase Cohort 1 (Steady State Dose of 100 mg OD Vandetanib + 25 mg BD Selumetinib) | Number of Serious Adverse Events, Non-serious Adverse Events and Treatment Emergent Adverse Events. | Total NSAEs | 99 Adverse events |
| Dose Escalation Phase Cohort 2 (Steady State Dose of 100 mg OD Vandetanib + 50 mg BD Selumetinib) | Number of Serious Adverse Events, Non-serious Adverse Events and Treatment Emergent Adverse Events. | Total treatment emergent AEs | 99 Adverse events |
| Dose Escalation Phase Cohort 2 (Steady State Dose of 100 mg OD Vandetanib + 50 mg BD Selumetinib) | Number of Serious Adverse Events, Non-serious Adverse Events and Treatment Emergent Adverse Events. | Total NSAEs | 90 Adverse events |
| Dose Escalation Phase Cohort 2 (Steady State Dose of 100 mg OD Vandetanib + 50 mg BD Selumetinib) | Number of Serious Adverse Events, Non-serious Adverse Events and Treatment Emergent Adverse Events. | Total SAEs | 11 Adverse events |
| Dose Escalation Phase Cohort 3 (Steady State Dose of 100 mg OD Vandetanib + 75 mg BD Selumetinib) | Number of Serious Adverse Events, Non-serious Adverse Events and Treatment Emergent Adverse Events. | Total treatment emergent AEs | 79 Adverse events |
| Dose Escalation Phase Cohort 3 (Steady State Dose of 100 mg OD Vandetanib + 75 mg BD Selumetinib) | Number of Serious Adverse Events, Non-serious Adverse Events and Treatment Emergent Adverse Events. | Total SAEs | 13 Adverse events |
| Dose Escalation Phase Cohort 3 (Steady State Dose of 100 mg OD Vandetanib + 75 mg BD Selumetinib) | Number of Serious Adverse Events, Non-serious Adverse Events and Treatment Emergent Adverse Events. | Total NSAEs | 70 Adverse events |
| Dose Escalation Phase Cohort 4 (Steady State Dose of 100 mg OD Vandetanib + 100 mg OD Selumetinib) | Number of Serious Adverse Events, Non-serious Adverse Events and Treatment Emergent Adverse Events. | Total SAEs | 5 Adverse events |
| Dose Escalation Phase Cohort 4 (Steady State Dose of 100 mg OD Vandetanib + 100 mg OD Selumetinib) | Number of Serious Adverse Events, Non-serious Adverse Events and Treatment Emergent Adverse Events. | Total NSAEs | 94 Adverse events |
| Dose Escalation Phase Cohort 4 (Steady State Dose of 100 mg OD Vandetanib + 100 mg OD Selumetinib) | Number of Serious Adverse Events, Non-serious Adverse Events and Treatment Emergent Adverse Events. | Total treatment emergent AEs | 93 Adverse events |
| Dose Escalation Phase Cohort 5a (Steady State Dose of 100 mg OD Vandetanib + 125 mg OD Selumetinib) | Number of Serious Adverse Events, Non-serious Adverse Events and Treatment Emergent Adverse Events. | Total NSAEs | 161 Adverse events |
| Dose Escalation Phase Cohort 5a (Steady State Dose of 100 mg OD Vandetanib + 125 mg OD Selumetinib) | Number of Serious Adverse Events, Non-serious Adverse Events and Treatment Emergent Adverse Events. | Total SAEs | 28 Adverse events |
| Dose Escalation Phase Cohort 5a (Steady State Dose of 100 mg OD Vandetanib + 125 mg OD Selumetinib) | Number of Serious Adverse Events, Non-serious Adverse Events and Treatment Emergent Adverse Events. | Total treatment emergent AEs | 165 Adverse events |
| Dose Escalation Phase Cohort 5b (Steady State Dose of 200 mg OD Vandetanib + 50 mg BD Selumetinib) | Number of Serious Adverse Events, Non-serious Adverse Events and Treatment Emergent Adverse Events. | Total NSAEs | 98 Adverse events |
| Dose Escalation Phase Cohort 5b (Steady State Dose of 200 mg OD Vandetanib + 50 mg BD Selumetinib) | Number of Serious Adverse Events, Non-serious Adverse Events and Treatment Emergent Adverse Events. | Total SAEs | 10 Adverse events |
| Dose Escalation Phase Cohort 5b (Steady State Dose of 200 mg OD Vandetanib + 50 mg BD Selumetinib) | Number of Serious Adverse Events, Non-serious Adverse Events and Treatment Emergent Adverse Events. | Total treatment emergent AEs | 102 Adverse events |
| Dose Escalation Phase Cohort 6 (Steady State Dose of 300 mg OD Vandetanib + 50 mg BD Selumetinib) | Number of Serious Adverse Events, Non-serious Adverse Events and Treatment Emergent Adverse Events. | Total NSAEs | 114 Adverse events |
| Dose Escalation Phase Cohort 6 (Steady State Dose of 300 mg OD Vandetanib + 50 mg BD Selumetinib) | Number of Serious Adverse Events, Non-serious Adverse Events and Treatment Emergent Adverse Events. | Total SAEs | 14 Adverse events |
| Dose Escalation Phase Cohort 6 (Steady State Dose of 300 mg OD Vandetanib + 50 mg BD Selumetinib) | Number of Serious Adverse Events, Non-serious Adverse Events and Treatment Emergent Adverse Events. | Total treatment emergent AEs | 126 Adverse events |
| Expansion Phase (Steady State Dose of 200 mg OD Vandetanib + 50 mg BD Selumetinib) | Number of Serious Adverse Events, Non-serious Adverse Events and Treatment Emergent Adverse Events. | Total SAEs | 14 Adverse events |
| Expansion Phase (Steady State Dose of 200 mg OD Vandetanib + 50 mg BD Selumetinib) | Number of Serious Adverse Events, Non-serious Adverse Events and Treatment Emergent Adverse Events. | Total NSAEs | 130 Adverse events |
| Expansion Phase (Steady State Dose of 200 mg OD Vandetanib + 50 mg BD Selumetinib) | Number of Serious Adverse Events, Non-serious Adverse Events and Treatment Emergent Adverse Events. | Total treatment emergent AEs | 135 Adverse events |
Secondary
Dose Escalation Cohorts Only: PK Parameter Area Under the Plasma Concentration Time Curve (0-12 Hours) of N-desmethyl Metabolite of Selumetinib.
Area under the plasma concentration time curve (0-12 hours) of N-desmethyl metabolite of selumetinib following the combination of vandetanib and selumetinib. This was extrapolated from the sampling data up to 10 hours to allow comparison with literature data.
Time frame: 0 hours (pre dose) and at 0.5, 2, 4, 6 and 10 hours post dose on Days 15 and 29.
Population: All patients in the dose escalation cohorts (Cohorts 1 to 6) who received at least one dose of IMP (N=47 with available PK data).
| Arm | Measure | Group | Value (MEDIAN) |
|---|---|---|---|
| Dose Escalation Phase Cohort 1 (Steady State Dose of 100 mg OD Vandetanib + 25 mg BD Selumetinib) | Dose Escalation Cohorts Only: PK Parameter Area Under the Plasma Concentration Time Curve (0-12 Hours) of N-desmethyl Metabolite of Selumetinib. | Day 15 | 78.5 h*ng/mL |
| Dose Escalation Phase Cohort 1 (Steady State Dose of 100 mg OD Vandetanib + 25 mg BD Selumetinib) | Dose Escalation Cohorts Only: PK Parameter Area Under the Plasma Concentration Time Curve (0-12 Hours) of N-desmethyl Metabolite of Selumetinib. | Day 29 | 89 h*ng/mL |
| Dose Escalation Phase Cohort 2 (Steady State Dose of 100 mg OD Vandetanib + 50 mg BD Selumetinib) | Dose Escalation Cohorts Only: PK Parameter Area Under the Plasma Concentration Time Curve (0-12 Hours) of N-desmethyl Metabolite of Selumetinib. | Day 15 | 141 h*ng/mL |
| Dose Escalation Phase Cohort 2 (Steady State Dose of 100 mg OD Vandetanib + 50 mg BD Selumetinib) | Dose Escalation Cohorts Only: PK Parameter Area Under the Plasma Concentration Time Curve (0-12 Hours) of N-desmethyl Metabolite of Selumetinib. | Day 29 | 163 h*ng/mL |
| Dose Escalation Phase Cohort 3 (Steady State Dose of 100 mg OD Vandetanib + 75 mg BD Selumetinib) | Dose Escalation Cohorts Only: PK Parameter Area Under the Plasma Concentration Time Curve (0-12 Hours) of N-desmethyl Metabolite of Selumetinib. | Day 15 | 255 h*ng/mL |
| Dose Escalation Phase Cohort 3 (Steady State Dose of 100 mg OD Vandetanib + 75 mg BD Selumetinib) | Dose Escalation Cohorts Only: PK Parameter Area Under the Plasma Concentration Time Curve (0-12 Hours) of N-desmethyl Metabolite of Selumetinib. | Day 29 | 230 h*ng/mL |
| Dose Escalation Phase Cohort 4 (Steady State Dose of 100 mg OD Vandetanib + 100 mg OD Selumetinib) | Dose Escalation Cohorts Only: PK Parameter Area Under the Plasma Concentration Time Curve (0-12 Hours) of N-desmethyl Metabolite of Selumetinib. | Day 15 | 349 h*ng/mL |
| Dose Escalation Phase Cohort 4 (Steady State Dose of 100 mg OD Vandetanib + 100 mg OD Selumetinib) | Dose Escalation Cohorts Only: PK Parameter Area Under the Plasma Concentration Time Curve (0-12 Hours) of N-desmethyl Metabolite of Selumetinib. | Day 29 | 390 h*ng/mL |
| Dose Escalation Phase Cohort 5a (Steady State Dose of 100 mg OD Vandetanib + 125 mg OD Selumetinib) | Dose Escalation Cohorts Only: PK Parameter Area Under the Plasma Concentration Time Curve (0-12 Hours) of N-desmethyl Metabolite of Selumetinib. | Day 15 | 493 h*ng/mL |
| Dose Escalation Phase Cohort 5a (Steady State Dose of 100 mg OD Vandetanib + 125 mg OD Selumetinib) | Dose Escalation Cohorts Only: PK Parameter Area Under the Plasma Concentration Time Curve (0-12 Hours) of N-desmethyl Metabolite of Selumetinib. | Day 29 | 377 h*ng/mL |
| Dose Escalation Phase Cohort 5b (Steady State Dose of 200 mg OD Vandetanib + 50 mg BD Selumetinib) | Dose Escalation Cohorts Only: PK Parameter Area Under the Plasma Concentration Time Curve (0-12 Hours) of N-desmethyl Metabolite of Selumetinib. | Day 15 | 182 h*ng/mL |
| Dose Escalation Phase Cohort 5b (Steady State Dose of 200 mg OD Vandetanib + 50 mg BD Selumetinib) | Dose Escalation Cohorts Only: PK Parameter Area Under the Plasma Concentration Time Curve (0-12 Hours) of N-desmethyl Metabolite of Selumetinib. | Day 29 | 293 h*ng/mL |
| Dose Escalation Phase Cohort 6 (Steady State Dose of 300 mg OD Vandetanib + 50 mg BD Selumetinib) | Dose Escalation Cohorts Only: PK Parameter Area Under the Plasma Concentration Time Curve (0-12 Hours) of N-desmethyl Metabolite of Selumetinib. | Day 15 | 236 h*ng/mL |
| Dose Escalation Phase Cohort 6 (Steady State Dose of 300 mg OD Vandetanib + 50 mg BD Selumetinib) | Dose Escalation Cohorts Only: PK Parameter Area Under the Plasma Concentration Time Curve (0-12 Hours) of N-desmethyl Metabolite of Selumetinib. | Day 29 | 205 h*ng/mL |
Secondary
Dose Escalation Cohorts Only: PK Parameter Area Under the Plasma Concentration Time Curve (0-12 Hours) of Selumetinib.
Area under the plasma concentration time curve (0-12 hours) of selumetinib post treatment with the combination of vandetanib and selumetinib. This was extrapolated from the sampling data up to 10 hours to allow comparison with literature data.
Time frame: 0 hours (pre dose) and at 0.5, 2, 4, 6 and 10 hours post dose on Days 15 and 29.
Population: All patients in the dose escalation cohorts (Cohorts 1 to 6) who received at least one dose of IMP (N=47 with available PK data).
| Arm | Measure | Group | Value (MEDIAN) |
|---|---|---|---|
| Dose Escalation Phase Cohort 1 (Steady State Dose of 100 mg OD Vandetanib + 25 mg BD Selumetinib) | Dose Escalation Cohorts Only: PK Parameter Area Under the Plasma Concentration Time Curve (0-12 Hours) of Selumetinib. | Day 15 | 1251.5 h*ng/mL |
| Dose Escalation Phase Cohort 1 (Steady State Dose of 100 mg OD Vandetanib + 25 mg BD Selumetinib) | Dose Escalation Cohorts Only: PK Parameter Area Under the Plasma Concentration Time Curve (0-12 Hours) of Selumetinib. | Day 29 | 1913 h*ng/mL |
| Dose Escalation Phase Cohort 2 (Steady State Dose of 100 mg OD Vandetanib + 50 mg BD Selumetinib) | Dose Escalation Cohorts Only: PK Parameter Area Under the Plasma Concentration Time Curve (0-12 Hours) of Selumetinib. | Day 15 | 2050 h*ng/mL |
| Dose Escalation Phase Cohort 2 (Steady State Dose of 100 mg OD Vandetanib + 50 mg BD Selumetinib) | Dose Escalation Cohorts Only: PK Parameter Area Under the Plasma Concentration Time Curve (0-12 Hours) of Selumetinib. | Day 29 | 2550 h*ng/mL |
| Dose Escalation Phase Cohort 3 (Steady State Dose of 100 mg OD Vandetanib + 75 mg BD Selumetinib) | Dose Escalation Cohorts Only: PK Parameter Area Under the Plasma Concentration Time Curve (0-12 Hours) of Selumetinib. | Day 15 | 4072.5 h*ng/mL |
| Dose Escalation Phase Cohort 3 (Steady State Dose of 100 mg OD Vandetanib + 75 mg BD Selumetinib) | Dose Escalation Cohorts Only: PK Parameter Area Under the Plasma Concentration Time Curve (0-12 Hours) of Selumetinib. | Day 29 | 4762 h*ng/mL |
| Dose Escalation Phase Cohort 4 (Steady State Dose of 100 mg OD Vandetanib + 100 mg OD Selumetinib) | Dose Escalation Cohorts Only: PK Parameter Area Under the Plasma Concentration Time Curve (0-12 Hours) of Selumetinib. | Day 15 | 6138 h*ng/mL |
| Dose Escalation Phase Cohort 4 (Steady State Dose of 100 mg OD Vandetanib + 100 mg OD Selumetinib) | Dose Escalation Cohorts Only: PK Parameter Area Under the Plasma Concentration Time Curve (0-12 Hours) of Selumetinib. | Day 29 | 6998 h*ng/mL |
| Dose Escalation Phase Cohort 5a (Steady State Dose of 100 mg OD Vandetanib + 125 mg OD Selumetinib) | Dose Escalation Cohorts Only: PK Parameter Area Under the Plasma Concentration Time Curve (0-12 Hours) of Selumetinib. | Day 15 | 6921 h*ng/mL |
| Dose Escalation Phase Cohort 5a (Steady State Dose of 100 mg OD Vandetanib + 125 mg OD Selumetinib) | Dose Escalation Cohorts Only: PK Parameter Area Under the Plasma Concentration Time Curve (0-12 Hours) of Selumetinib. | Day 29 | 6429 h*ng/mL |
| Dose Escalation Phase Cohort 5b (Steady State Dose of 200 mg OD Vandetanib + 50 mg BD Selumetinib) | Dose Escalation Cohorts Only: PK Parameter Area Under the Plasma Concentration Time Curve (0-12 Hours) of Selumetinib. | Day 15 | 1698 h*ng/mL |
| Dose Escalation Phase Cohort 5b (Steady State Dose of 200 mg OD Vandetanib + 50 mg BD Selumetinib) | Dose Escalation Cohorts Only: PK Parameter Area Under the Plasma Concentration Time Curve (0-12 Hours) of Selumetinib. | Day 29 | 3049 h*ng/mL |
| Dose Escalation Phase Cohort 6 (Steady State Dose of 300 mg OD Vandetanib + 50 mg BD Selumetinib) | Dose Escalation Cohorts Only: PK Parameter Area Under the Plasma Concentration Time Curve (0-12 Hours) of Selumetinib. | Day 15 | 2770 h*ng/mL |
| Dose Escalation Phase Cohort 6 (Steady State Dose of 300 mg OD Vandetanib + 50 mg BD Selumetinib) | Dose Escalation Cohorts Only: PK Parameter Area Under the Plasma Concentration Time Curve (0-12 Hours) of Selumetinib. | Day 29 | 2477 h*ng/mL |
Secondary
Dose Escalation Cohorts Only: PK Parameter Area Under the Plasma Concentration Time Curve (0-24 Hours) of Vandetanib.
Area under the plasma concentration time curve (0-24 hours) of vandetanib post treatment with vandetanib alone and following the combination of vandetanib and selumetinib.
Time frame: 0 hours (pre dose) and at 0.5, 2, 4, 6 and 24 hours post dose on Day 4. 0 hours (pre dose) and at 0.5, 2, 4, 6, 10 and 24 hours post dose on Days 15 and 29.
Population: All patients in the dose escalation cohorts (Cohorts 1 to 6) who received at least one dose of IMP (N=47 with available PK data).
| Arm | Measure | Group | Value (MEDIAN) |
|---|---|---|---|
| Dose Escalation Phase Cohort 1 (Steady State Dose of 100 mg OD Vandetanib + 25 mg BD Selumetinib) | Dose Escalation Cohorts Only: PK Parameter Area Under the Plasma Concentration Time Curve (0-24 Hours) of Vandetanib. | Day 29 | 12555 h*ng/mL |
| Dose Escalation Phase Cohort 1 (Steady State Dose of 100 mg OD Vandetanib + 25 mg BD Selumetinib) | Dose Escalation Cohorts Only: PK Parameter Area Under the Plasma Concentration Time Curve (0-24 Hours) of Vandetanib. | Day 15 | 9253.5 h*ng/mL |
| Dose Escalation Phase Cohort 1 (Steady State Dose of 100 mg OD Vandetanib + 25 mg BD Selumetinib) | Dose Escalation Cohorts Only: PK Parameter Area Under the Plasma Concentration Time Curve (0-24 Hours) of Vandetanib. | Day 4 | 12032 h*ng/mL |
| Dose Escalation Phase Cohort 2 (Steady State Dose of 100 mg OD Vandetanib + 50 mg BD Selumetinib) | Dose Escalation Cohorts Only: PK Parameter Area Under the Plasma Concentration Time Curve (0-24 Hours) of Vandetanib. | Day 15 | 8822.5 h*ng/mL |
| Dose Escalation Phase Cohort 2 (Steady State Dose of 100 mg OD Vandetanib + 50 mg BD Selumetinib) | Dose Escalation Cohorts Only: PK Parameter Area Under the Plasma Concentration Time Curve (0-24 Hours) of Vandetanib. | Day 4 | 11629.5 h*ng/mL |
| Dose Escalation Phase Cohort 2 (Steady State Dose of 100 mg OD Vandetanib + 50 mg BD Selumetinib) | Dose Escalation Cohorts Only: PK Parameter Area Under the Plasma Concentration Time Curve (0-24 Hours) of Vandetanib. | Day 29 | 8355 h*ng/mL |
| Dose Escalation Phase Cohort 3 (Steady State Dose of 100 mg OD Vandetanib + 75 mg BD Selumetinib) | Dose Escalation Cohorts Only: PK Parameter Area Under the Plasma Concentration Time Curve (0-24 Hours) of Vandetanib. | Day 29 | 11246 h*ng/mL |
| Dose Escalation Phase Cohort 3 (Steady State Dose of 100 mg OD Vandetanib + 75 mg BD Selumetinib) | Dose Escalation Cohorts Only: PK Parameter Area Under the Plasma Concentration Time Curve (0-24 Hours) of Vandetanib. | Day 4 | 11189 h*ng/mL |
| Dose Escalation Phase Cohort 3 (Steady State Dose of 100 mg OD Vandetanib + 75 mg BD Selumetinib) | Dose Escalation Cohorts Only: PK Parameter Area Under the Plasma Concentration Time Curve (0-24 Hours) of Vandetanib. | Day 15 | 7958.5 h*ng/mL |
| Dose Escalation Phase Cohort 4 (Steady State Dose of 100 mg OD Vandetanib + 100 mg OD Selumetinib) | Dose Escalation Cohorts Only: PK Parameter Area Under the Plasma Concentration Time Curve (0-24 Hours) of Vandetanib. | Day 15 | 9946 h*ng/mL |
| Dose Escalation Phase Cohort 4 (Steady State Dose of 100 mg OD Vandetanib + 100 mg OD Selumetinib) | Dose Escalation Cohorts Only: PK Parameter Area Under the Plasma Concentration Time Curve (0-24 Hours) of Vandetanib. | Day 4 | 16603 h*ng/mL |
| Dose Escalation Phase Cohort 4 (Steady State Dose of 100 mg OD Vandetanib + 100 mg OD Selumetinib) | Dose Escalation Cohorts Only: PK Parameter Area Under the Plasma Concentration Time Curve (0-24 Hours) of Vandetanib. | Day 29 | 10058 h*ng/mL |
| Dose Escalation Phase Cohort 5a (Steady State Dose of 100 mg OD Vandetanib + 125 mg OD Selumetinib) | Dose Escalation Cohorts Only: PK Parameter Area Under the Plasma Concentration Time Curve (0-24 Hours) of Vandetanib. | Day 15 | 8814.5 h*ng/mL |
| Dose Escalation Phase Cohort 5a (Steady State Dose of 100 mg OD Vandetanib + 125 mg OD Selumetinib) | Dose Escalation Cohorts Only: PK Parameter Area Under the Plasma Concentration Time Curve (0-24 Hours) of Vandetanib. | Day 4 | 10286.5 h*ng/mL |
| Dose Escalation Phase Cohort 5a (Steady State Dose of 100 mg OD Vandetanib + 125 mg OD Selumetinib) | Dose Escalation Cohorts Only: PK Parameter Area Under the Plasma Concentration Time Curve (0-24 Hours) of Vandetanib. | Day 29 | 7261.5 h*ng/mL |
| Dose Escalation Phase Cohort 5b (Steady State Dose of 200 mg OD Vandetanib + 50 mg BD Selumetinib) | Dose Escalation Cohorts Only: PK Parameter Area Under the Plasma Concentration Time Curve (0-24 Hours) of Vandetanib. | Day 4 | 14395 h*ng/mL |
| Dose Escalation Phase Cohort 5b (Steady State Dose of 200 mg OD Vandetanib + 50 mg BD Selumetinib) | Dose Escalation Cohorts Only: PK Parameter Area Under the Plasma Concentration Time Curve (0-24 Hours) of Vandetanib. | Day 29 | 18573 h*ng/mL |
| Dose Escalation Phase Cohort 5b (Steady State Dose of 200 mg OD Vandetanib + 50 mg BD Selumetinib) | Dose Escalation Cohorts Only: PK Parameter Area Under the Plasma Concentration Time Curve (0-24 Hours) of Vandetanib. | Day 15 | 15442 h*ng/mL |
| Dose Escalation Phase Cohort 6 (Steady State Dose of 300 mg OD Vandetanib + 50 mg BD Selumetinib) | Dose Escalation Cohorts Only: PK Parameter Area Under the Plasma Concentration Time Curve (0-24 Hours) of Vandetanib. | Day 29 | 15923 h*ng/mL |
| Dose Escalation Phase Cohort 6 (Steady State Dose of 300 mg OD Vandetanib + 50 mg BD Selumetinib) | Dose Escalation Cohorts Only: PK Parameter Area Under the Plasma Concentration Time Curve (0-24 Hours) of Vandetanib. | Day 15 | 18864 h*ng/mL |
| Dose Escalation Phase Cohort 6 (Steady State Dose of 300 mg OD Vandetanib + 50 mg BD Selumetinib) | Dose Escalation Cohorts Only: PK Parameter Area Under the Plasma Concentration Time Curve (0-24 Hours) of Vandetanib. | Day 4 | 14830.5 h*ng/mL |
Secondary
Dose Escalation Cohorts Only: PK Parameter Maximum Observed Plasma Concentration of Selumetinib.
Maximum observed plasma concentration of selumetinib post treatment with the combination of vandetanib and selumetinib.
Time frame: 0 hours (pre dose) and at 0.5, 2, 4, 6, 10 and 24 hours post dose on Days 15 and 29.
Population: All patients in the dose escalation cohorts (Cohorts 1 to 6) who received at least one dose of IMP (N=47 with available PK data).
| Arm | Measure | Group | Value (MEDIAN) |
|---|---|---|---|
| Dose Escalation Phase Cohort 1 (Steady State Dose of 100 mg OD Vandetanib + 25 mg BD Selumetinib) | Dose Escalation Cohorts Only: PK Parameter Maximum Observed Plasma Concentration of Selumetinib. | Day 15 | 324.5 ng/mL |
| Dose Escalation Phase Cohort 1 (Steady State Dose of 100 mg OD Vandetanib + 25 mg BD Selumetinib) | Dose Escalation Cohorts Only: PK Parameter Maximum Observed Plasma Concentration of Selumetinib. | Day 29 | 430 ng/mL |
| Dose Escalation Phase Cohort 2 (Steady State Dose of 100 mg OD Vandetanib + 50 mg BD Selumetinib) | Dose Escalation Cohorts Only: PK Parameter Maximum Observed Plasma Concentration of Selumetinib. | Day 15 | 605 ng/mL |
| Dose Escalation Phase Cohort 2 (Steady State Dose of 100 mg OD Vandetanib + 50 mg BD Selumetinib) | Dose Escalation Cohorts Only: PK Parameter Maximum Observed Plasma Concentration of Selumetinib. | Day 29 | 569 ng/mL |
| Dose Escalation Phase Cohort 3 (Steady State Dose of 100 mg OD Vandetanib + 75 mg BD Selumetinib) | Dose Escalation Cohorts Only: PK Parameter Maximum Observed Plasma Concentration of Selumetinib. | Day 15 | 1280 ng/mL |
| Dose Escalation Phase Cohort 3 (Steady State Dose of 100 mg OD Vandetanib + 75 mg BD Selumetinib) | Dose Escalation Cohorts Only: PK Parameter Maximum Observed Plasma Concentration of Selumetinib. | Day 29 | 1220 ng/mL |
| Dose Escalation Phase Cohort 4 (Steady State Dose of 100 mg OD Vandetanib + 100 mg OD Selumetinib) | Dose Escalation Cohorts Only: PK Parameter Maximum Observed Plasma Concentration of Selumetinib. | Day 15 | 1890 ng/mL |
| Dose Escalation Phase Cohort 4 (Steady State Dose of 100 mg OD Vandetanib + 100 mg OD Selumetinib) | Dose Escalation Cohorts Only: PK Parameter Maximum Observed Plasma Concentration of Selumetinib. | Day 29 | 1740 ng/mL |
| Dose Escalation Phase Cohort 5a (Steady State Dose of 100 mg OD Vandetanib + 125 mg OD Selumetinib) | Dose Escalation Cohorts Only: PK Parameter Maximum Observed Plasma Concentration of Selumetinib. | Day 15 | 2005 ng/mL |
| Dose Escalation Phase Cohort 5a (Steady State Dose of 100 mg OD Vandetanib + 125 mg OD Selumetinib) | Dose Escalation Cohorts Only: PK Parameter Maximum Observed Plasma Concentration of Selumetinib. | Day 29 | 1440 ng/mL |
| Dose Escalation Phase Cohort 5b (Steady State Dose of 200 mg OD Vandetanib + 50 mg BD Selumetinib) | Dose Escalation Cohorts Only: PK Parameter Maximum Observed Plasma Concentration of Selumetinib. | Day 15 | 501 ng/mL |
| Dose Escalation Phase Cohort 5b (Steady State Dose of 200 mg OD Vandetanib + 50 mg BD Selumetinib) | Dose Escalation Cohorts Only: PK Parameter Maximum Observed Plasma Concentration of Selumetinib. | Day 29 | 587 ng/mL |
| Dose Escalation Phase Cohort 6 (Steady State Dose of 300 mg OD Vandetanib + 50 mg BD Selumetinib) | Dose Escalation Cohorts Only: PK Parameter Maximum Observed Plasma Concentration of Selumetinib. | Day 15 | 814 ng/mL |
| Dose Escalation Phase Cohort 6 (Steady State Dose of 300 mg OD Vandetanib + 50 mg BD Selumetinib) | Dose Escalation Cohorts Only: PK Parameter Maximum Observed Plasma Concentration of Selumetinib. | Day 29 | 593 ng/mL |
Secondary
Dose Escalation Cohorts Only: PK Parameter Maximum Observed Plasma Concentration of Vandetanib.
Maximum observed plasma concentration of vandetanib post treatment with vandetanib alone and following the combination of vandetanib and selumetinib.
Time frame: 0 hours (pre dose) and at 0.5, 2, 4, 6 and 24 hours post dose on Day 4. 0 hours (pre dose) and at 0.5, 2, 4, 6, 10 and 24 hours post dose on Days 15 and 29.
Population: All patients in the dose escalation cohorts (Cohorts 1 to 6) who received at least one dose of IMP (N=47 with available PK data).
| Arm | Measure | Group | Value (MEDIAN) |
|---|---|---|---|
| Dose Escalation Phase Cohort 1 (Steady State Dose of 100 mg OD Vandetanib + 25 mg BD Selumetinib) | Dose Escalation Cohorts Only: PK Parameter Maximum Observed Plasma Concentration of Vandetanib. | Day 15 | 503.5 ng/mL |
| Dose Escalation Phase Cohort 1 (Steady State Dose of 100 mg OD Vandetanib + 25 mg BD Selumetinib) | Dose Escalation Cohorts Only: PK Parameter Maximum Observed Plasma Concentration of Vandetanib. | Day 29 | 556 ng/mL |
| Dose Escalation Phase Cohort 1 (Steady State Dose of 100 mg OD Vandetanib + 25 mg BD Selumetinib) | Dose Escalation Cohorts Only: PK Parameter Maximum Observed Plasma Concentration of Vandetanib. | Day 4 | 585 ng/mL |
| Dose Escalation Phase Cohort 2 (Steady State Dose of 100 mg OD Vandetanib + 50 mg BD Selumetinib) | Dose Escalation Cohorts Only: PK Parameter Maximum Observed Plasma Concentration of Vandetanib. | Day 15 | 436 ng/mL |
| Dose Escalation Phase Cohort 2 (Steady State Dose of 100 mg OD Vandetanib + 50 mg BD Selumetinib) | Dose Escalation Cohorts Only: PK Parameter Maximum Observed Plasma Concentration of Vandetanib. | Day 4 | 561 ng/mL |
| Dose Escalation Phase Cohort 2 (Steady State Dose of 100 mg OD Vandetanib + 50 mg BD Selumetinib) | Dose Escalation Cohorts Only: PK Parameter Maximum Observed Plasma Concentration of Vandetanib. | Day 29 | 399 ng/mL |
| Dose Escalation Phase Cohort 3 (Steady State Dose of 100 mg OD Vandetanib + 75 mg BD Selumetinib) | Dose Escalation Cohorts Only: PK Parameter Maximum Observed Plasma Concentration of Vandetanib. | Day 15 | 414.5 ng/mL |
| Dose Escalation Phase Cohort 3 (Steady State Dose of 100 mg OD Vandetanib + 75 mg BD Selumetinib) | Dose Escalation Cohorts Only: PK Parameter Maximum Observed Plasma Concentration of Vandetanib. | Day 4 | 582 ng/mL |
| Dose Escalation Phase Cohort 3 (Steady State Dose of 100 mg OD Vandetanib + 75 mg BD Selumetinib) | Dose Escalation Cohorts Only: PK Parameter Maximum Observed Plasma Concentration of Vandetanib. | Day 29 | 538 ng/mL |
| Dose Escalation Phase Cohort 4 (Steady State Dose of 100 mg OD Vandetanib + 100 mg OD Selumetinib) | Dose Escalation Cohorts Only: PK Parameter Maximum Observed Plasma Concentration of Vandetanib. | Day 4 | 790 ng/mL |
| Dose Escalation Phase Cohort 4 (Steady State Dose of 100 mg OD Vandetanib + 100 mg OD Selumetinib) | Dose Escalation Cohorts Only: PK Parameter Maximum Observed Plasma Concentration of Vandetanib. | Day 29 | 503 ng/mL |
| Dose Escalation Phase Cohort 4 (Steady State Dose of 100 mg OD Vandetanib + 100 mg OD Selumetinib) | Dose Escalation Cohorts Only: PK Parameter Maximum Observed Plasma Concentration of Vandetanib. | Day 15 | 476 ng/mL |
| Dose Escalation Phase Cohort 5a (Steady State Dose of 100 mg OD Vandetanib + 125 mg OD Selumetinib) | Dose Escalation Cohorts Only: PK Parameter Maximum Observed Plasma Concentration of Vandetanib. | Day 15 | 401.5 ng/mL |
| Dose Escalation Phase Cohort 5a (Steady State Dose of 100 mg OD Vandetanib + 125 mg OD Selumetinib) | Dose Escalation Cohorts Only: PK Parameter Maximum Observed Plasma Concentration of Vandetanib. | Day 4 | 484.5 ng/mL |
| Dose Escalation Phase Cohort 5a (Steady State Dose of 100 mg OD Vandetanib + 125 mg OD Selumetinib) | Dose Escalation Cohorts Only: PK Parameter Maximum Observed Plasma Concentration of Vandetanib. | Day 29 | 335.5 ng/mL |
| Dose Escalation Phase Cohort 5b (Steady State Dose of 200 mg OD Vandetanib + 50 mg BD Selumetinib) | Dose Escalation Cohorts Only: PK Parameter Maximum Observed Plasma Concentration of Vandetanib. | Day 15 | 701 ng/mL |
| Dose Escalation Phase Cohort 5b (Steady State Dose of 200 mg OD Vandetanib + 50 mg BD Selumetinib) | Dose Escalation Cohorts Only: PK Parameter Maximum Observed Plasma Concentration of Vandetanib. | Day 29 | 988 ng/mL |
| Dose Escalation Phase Cohort 5b (Steady State Dose of 200 mg OD Vandetanib + 50 mg BD Selumetinib) | Dose Escalation Cohorts Only: PK Parameter Maximum Observed Plasma Concentration of Vandetanib. | Day 4 | 702.5 ng/mL |
| Dose Escalation Phase Cohort 6 (Steady State Dose of 300 mg OD Vandetanib + 50 mg BD Selumetinib) | Dose Escalation Cohorts Only: PK Parameter Maximum Observed Plasma Concentration of Vandetanib. | Day 29 | 902 ng/mL |
| Dose Escalation Phase Cohort 6 (Steady State Dose of 300 mg OD Vandetanib + 50 mg BD Selumetinib) | Dose Escalation Cohorts Only: PK Parameter Maximum Observed Plasma Concentration of Vandetanib. | Day 4 | 702 ng/mL |
| Dose Escalation Phase Cohort 6 (Steady State Dose of 300 mg OD Vandetanib + 50 mg BD Selumetinib) | Dose Escalation Cohorts Only: PK Parameter Maximum Observed Plasma Concentration of Vandetanib. | Day 15 | 906 ng/mL |
Secondary
Expansion Cohort Only: One Year Survival of Patients With NSCLC After Treatment With the Combination of Vandetanib and Selumetinib.
Number of patients alive at one year.
Time frame: 1 year from date of first dose of vandetanib.
Population: All patients in the expansion cohort receiving at least one cycle\* of the vandetanib and selumetinib combination with a baseline assessment of disease (N=9).~\*To be evaluable for response, a patient must have received a minimum of 21 of the 28 daily doses of the combination treatment in Cycle 1.
| Arm | Measure | Value (NUMBER) |
|---|---|---|
| Dose Escalation Phase Cohort 1 (Steady State Dose of 100 mg OD Vandetanib + 25 mg BD Selumetinib) | Expansion Cohort Only: One Year Survival of Patients With NSCLC After Treatment With the Combination of Vandetanib and Selumetinib. | 2 participants |
Secondary
Expansion Cohort Only: Progression Free Survival (PFS) of Patients With NSCLC After Treatment With the Combination of Vandetanib and Selumetinib.
PFS by Response Evaluation Criteria in Solid Tumours Criteria (RECIST v1.0). Per RECIST for target lesions and assessed by computerised tomography (CT), progressive disease was defined as at least a 20% increase in the sum of diameters of target lesions, taking as reference the smallest sum while on trial, or the appearance of one or more new lesions.
Time frame: 10 and 18 weeks from date of first dose of vandetanib.
Population: All patients in the expansion cohort receiving at least one cycle\* of the vandetanib and selumetinib combination with a baseline assessment of disease (N=9).~\*To be evaluable for response, a patient must have received a minimum of 21 of the 28 daily doses of the combination treatment in Cycle 1.
| Arm | Measure | Group | Value (NUMBER) |
|---|---|---|---|
| Dose Escalation Phase Cohort 1 (Steady State Dose of 100 mg OD Vandetanib + 25 mg BD Selumetinib) | Expansion Cohort Only: Progression Free Survival (PFS) of Patients With NSCLC After Treatment With the Combination of Vandetanib and Selumetinib. | Progression free at 10 weeks | 3 participants |
| Dose Escalation Phase Cohort 1 (Steady State Dose of 100 mg OD Vandetanib + 25 mg BD Selumetinib) | Expansion Cohort Only: Progression Free Survival (PFS) of Patients With NSCLC After Treatment With the Combination of Vandetanib and Selumetinib. | Progression free at 18 weeks | 2 participants |
Secondary
Expansion Cohort Only: Tumour Metabolism in Patients With NSCLC Using Positron Emission Tomography Response Criteria in Solid Tumours (PERCIST) Criteria.
Tumour metabolism using 18F-fluorodeoxyglucose positron emission tomography (\[18F\]FDG-PET) computerised tomography (CT) imaging pre and post treatment with vandetanib alone and following the combination of vandetanib and selumetinib. These were assessed and reported according to PERCIST criteria.
Time frame: Baseline, Day 12, Day 42.
Population: All patients in the expansion cohort receiving at least one cycle\* of the vandetanib and selumetinib combination with a baseline assessment of disease (N=9).~\*To be evaluable for response, a patient must have received a minimum of 21 of the 28 daily doses of the combination treatment in Cycle 1.
| Arm | Measure | Group | Value (NUMBER) |
|---|---|---|---|
| Dose Escalation Phase Cohort 1 (Steady State Dose of 100 mg OD Vandetanib + 25 mg BD Selumetinib) | Expansion Cohort Only: Tumour Metabolism in Patients With NSCLC Using Positron Emission Tomography Response Criteria in Solid Tumours (PERCIST) Criteria. | Day 12 Complete Metabolic Response | 0 participants |
| Dose Escalation Phase Cohort 1 (Steady State Dose of 100 mg OD Vandetanib + 25 mg BD Selumetinib) | Expansion Cohort Only: Tumour Metabolism in Patients With NSCLC Using Positron Emission Tomography Response Criteria in Solid Tumours (PERCIST) Criteria. | Day 12 Partial Metabolic Response | 0 participants |
| Dose Escalation Phase Cohort 1 (Steady State Dose of 100 mg OD Vandetanib + 25 mg BD Selumetinib) | Expansion Cohort Only: Tumour Metabolism in Patients With NSCLC Using Positron Emission Tomography Response Criteria in Solid Tumours (PERCIST) Criteria. | Day 12 Stable Metabolic Disease | 8 participants |
| Dose Escalation Phase Cohort 1 (Steady State Dose of 100 mg OD Vandetanib + 25 mg BD Selumetinib) | Expansion Cohort Only: Tumour Metabolism in Patients With NSCLC Using Positron Emission Tomography Response Criteria in Solid Tumours (PERCIST) Criteria. | Day 12 Progressive Metabolic Disease | 1 participants |
| Dose Escalation Phase Cohort 1 (Steady State Dose of 100 mg OD Vandetanib + 25 mg BD Selumetinib) | Expansion Cohort Only: Tumour Metabolism in Patients With NSCLC Using Positron Emission Tomography Response Criteria in Solid Tumours (PERCIST) Criteria. | Day 42 Complete Metabolic Response | 0 participants |
| Dose Escalation Phase Cohort 1 (Steady State Dose of 100 mg OD Vandetanib + 25 mg BD Selumetinib) | Expansion Cohort Only: Tumour Metabolism in Patients With NSCLC Using Positron Emission Tomography Response Criteria in Solid Tumours (PERCIST) Criteria. | Day 42 Partial Metabolic Response | 2 participants |
| Dose Escalation Phase Cohort 1 (Steady State Dose of 100 mg OD Vandetanib + 25 mg BD Selumetinib) | Expansion Cohort Only: Tumour Metabolism in Patients With NSCLC Using Positron Emission Tomography Response Criteria in Solid Tumours (PERCIST) Criteria. | Day 42 Stable Metabolic Disease | 3 participants |
| Dose Escalation Phase Cohort 1 (Steady State Dose of 100 mg OD Vandetanib + 25 mg BD Selumetinib) | Expansion Cohort Only: Tumour Metabolism in Patients With NSCLC Using Positron Emission Tomography Response Criteria in Solid Tumours (PERCIST) Criteria. | Day 42 Progressive Metabolic Disease | 2 participants |
| Dose Escalation Phase Cohort 1 (Steady State Dose of 100 mg OD Vandetanib + 25 mg BD Selumetinib) | Expansion Cohort Only: Tumour Metabolism in Patients With NSCLC Using Positron Emission Tomography Response Criteria in Solid Tumours (PERCIST) Criteria. | Day 42 Not assessed | 2 participants |