Pleuro-pneumonia
Conditions
Keywords
pleuropneumonia children, non steroidal anti inflammatory drugs, pleural effusion, severe pneumonia
Brief summary
The purpose of this study is to evaluate the influence of routine NSAIDs treatment for hospitalized children with pleuropneumonia in comparison with acetominophen treatment (all in conjunction with adequate antibiotic therapy).
Interventions
DRUGIbuprofen
10 mg/kg every 8 hours until 24 hours after resolution of fever
DRUGAcetaminophen
15 mg/kg every 6 hours until 24 hours after resolution of fever
Sponsors
Rabin Medical Center
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
No minimum to 18 Years
Healthy volunteers
No
Inclusion criteria
* age less than 18 years * admission in Schneider childrenMC of Israel, wards a/c * clinical diagnosis of pneumonia with evidence of pleural effusion on chest X-ray * parental informed consent * follow-up ability after discharge
Exclusion criteria
* pneumonia secondary to foreign body aspiration * immune deficiency * chronic lung disease other than asthma (CF, CLD of prematurity, Familial Dysautonomia, etc) * significant premorbidity (organ failure, rheumatic disease, etc) * endotracheal/endobronchial devices including tracheostomy. * parental refusal to participate in the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| clinical improvement as manifested by resolution of fever and length of hospital admission. | participants will be followed for the duration of hospital stay, an expected average of 10 days |
Secondary
| Measure | Time frame |
|---|---|
| clinical improvement as manifested by respiratory parameters (tachypnea, dyspnea, Fio2),and inflammatory markers. | participants will be followed for the duration of hospital stay, an expected average of 10 days |
Countries
Israel
Contacts
Primary Contactshai ashkenazi, Prof
Backup Contacthavatzelet yarden-bilavsky, Dr
Outcome results
None listed