Unilateral Knee Osteoarthritis
Conditions
Keywords
Knee Osteoarthritis, Exercise, Isokinetic, Muscle strength, Rehabilitation
Brief summary
Knee osteoarthritis (O.A. from now on) is associated to muscular weakness of inferior limbs, especially the quadriceps; leading to disease progression. Advantages of muscular strength training for the treatment of this kind of O.A. is now well established. In this therapeutic field, isokinetic exercises seem to have a better efficiency than other, more frequently used, kinds of exercises such as isometric or isotonic exercises. Functional impairment caused by knee O.A. is mainly affecting walking. Walking induces muscles to work in eccentric mode. The hypothesis of this study is that muscular strengthening using isokinetic exercises in eccentric mode would have a more important benefit than isokinetic exercises in concentric mode. Such an hypothesis, if verified, could lead to a better management of rehabilitative knee exercises in the treatment of knee O.A.
Detailed description
Knee osteoarthritis (O.A. from now on) is associated to muscular weakness of inferior limbs, especially the quadriceps; leading to disease progression. Advantages of muscular strength training for the treatment of this kind of O.A. is now well established. In this therapeutic field, isokinetic exercises seem to have a better efficiency than other, more frequently used, kinds of exercises such as isometric or isotonic exercises. Functional impairment caused by knee O.A. is mainly affecting walking. Walking induces muscles to work in eccentric mode. The hypothesis of this study is that muscular strengthening using isokinetic exercises in eccentric mode would have a more important benefit than isokinetic exercises in concentric mode. Such an hypothesis, if verified, could lead to a better management of rehabilitative knee exercises in the treatment of knee O.A.
Interventions
OTHERExercise in eccentric or concentric mode
In this therapeutic field, isokinetic exercises seem to have a better efficiency than other, more frequently used, kinds of exercises such as isometric or isotonic exercises.
Sponsors
University Hospital, Clermont-Ferrand
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
OTHER
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
ALL
Age
40 Years to 70 Years
Healthy volunteers
No
Inclusion criteria
* Patient male or female, age ranging from 40 to 70 years old * Patient suffering from one-sided knee O.A. regarding criteria of the American College of Rheumatology (A.C.R.), with radiologic score ranging from 2 to 3 according to the Kellgren \& Lawrence classification. * Patient receiving medical support * Patient that did not receive any infiltration on knee within two months before randomisation. * Patient free from any disease that could be a contraindication to the study treatment * Patient able to understand the protocol and willing to comply with its rules. * Patient willing to give consent. * Patient affiliated to the french social secu
Exclusion criteria
* Patient carrying prosthesis. * Patient suffering from inflammatory arthritis, or flare of arthritis. * Patient suffering from symptomatic patellofemoral osteoarthritis. * Patient suffering from cardio-vascular or pneumologic disease that could a contraindication to the study treatment. * Patient suffering from any pathology that could cause muscular weakness (myopathy, neuropathy, hemiplegia...)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Difference of peak torque of quadriceps | 6 months after treatment start |
Secondary
| Measure | Time frame |
|---|---|
| Walk speed (50 meters and 200 meters) | at day 1, 6 weeks, and 6 months : |
| Knee pain (via analogic visual scales) | at day 1, 6 weeks, and 6 months |
| Posture parameters (posturography) | at day 1, 6 weeks, and 6 months |
| WOMAC Scores | at day 1, 6 weeks, and 6 months |
| Knee perimeter | at day 1, 6 weeks, and 6 months |
| Knee range of motion (goniometer) | at day 1, 6 weeks, and 6 months |
| Kellgren & Lawrence scores | at day 1, 6 weeks, and 6 months |
Countries
France
Contacts
PRINCIPAL_INVESTIGATOREmmanuel COUDEYRE
University Hospital, Clermont-Ferrand
Outcome results
None listed