Study of the Effect of Diabetes on the Incidence and the Extent of Coronary Artery Disease

The Role of Newer and Traditional Risk Factors in the Development, Extent and Manifestation of Coronary Artery Disease

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT01585948

Enrollment

1104

Registered

2012-04-26

Start date

2009-11-30

Completion date

2020-03-31

Last updated

2020-03-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Patients Undergoing Coronary Angiography

Brief summary

In the present study the investigators will measure the extent of coronary artery disease via coronary angiography and the correlating risk factors.

Detailed description

In the present study the investigators will examine the risk factors determining the development, extent and the manifestation of coronary artery disease. The study will recruit patients undergoing coronary angiography for clinical purposes.

Interventions

None listed

Study design

Observational model

CASE_CONTROL

Time perspective

CROSS_SECTIONAL

Eligibility

Sex/Gender

ALL

Age

18 Years to 90 Years

Healthy volunteers

Inclusion criteria

* Any subject eligible for coronary angiography with or without known CV disease for clinical reasons.

Exclusion criteria

* Patients revascularized in the past, with either coronary artery bypass grafting or percutaneous coronary intervention, will be excluded from the study since it is not possible to describe the extent of CAD in these patients. * Moderate or severe aortic stenosis.

Design outcomes

Primary

Measure	Time frame	Description
The incidence and extent of coronary artery disease between diabetics and non-diabetic patients.	Up to four years on average.	We will investigate the incidence, extent and clinical manifestation of coronary artery disease in diabetics and non-diabetics undergoing coronary angiography for clinical reasons.

Secondary

Measure	Time frame	Description
The incidence and extent of coronary artery disease via coronary angiography scores and related biochemical and demographical risk factors.	Up to 4 years on average.	To associate the incidence, extent and clinical manifestation of coronary artery disease with classic demographic risk factors (such as smoking, alcohol consumption, physical exercise, arterial hypertension, family history of diabetes mellitus or coronary artery disease) and common biochemical risk factors (such as fasting glucose levels, urea, creatinine, HbA1c%, uric acid, total cholesterol, HDL, LDL, triglycerides, VLDL, glomerular filtration rate - GFR).
The incidence, extent and clinical manifestation of coronary artery disease and the circulating levels of hs-CRP, adipokines and RAGEs.	Up to 4 years on average.	To associate the incidence, extent and clinical manifestation of coronary artery disease with systemic inflammatory status assessed by hs-CRP levels, circulating adipokines (adiponectin, resistin) and the receptors of advanced glycation end products (sRAGE and esRAGE).
TCF7L2 gene polymorphims and the incidence and extent of coronary artery disease.	Within a maximum period of 4 years.	To associate the incidence, extent and clinical manifestation of coronary artery disease with the rs7903146 single nucleotide polymorphism of TCF7L2 gene, that has been strongly associated with diabetes mellitus development.

Countries

Greece

Outcome results