Studying Gene Expression and Location in Samples From Patients With Brain Tumors

Expression and Subcellular Localization of NEIL3 in Tumors

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT01585389

Enrollment

Registered

2012-04-25

Start date

2012-04-30

Completion date

Unknown

Last updated

2016-05-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Brain and Central Nervous System Tumors

Keywords

adult brain tumor, childhood brain tumor

Brief summary

RATIONALE: Studying samples of tumor tissue from patients with cancer in the laboratory may help doctors identify and learn more about biomarkers related to brain tumors. PURPOSE: This research studies gene expression and location in samples from patients with brain tumors.

Detailed description

OBJECTIVES: * To determine the expression and subcellular localization of nei endonuclease VIII-like 3 (NEIL3) in brain tumors. OUTLINE: Tissue microarray samples are analyzed for NEIL3 expression and subcellular localization by immunohistochemical methods.

Interventions

GENETICgene expression analysis

GENETICgenetic linkage analysis

GENETICmicroarray analysis

OTHERimmunohistochemistry staining method

OTHERlaboratory biomarker analysis

Study design

Observational model

CASE_ONLY

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

ALL

Healthy volunteers

Inclusion criteria

DISEASE CHARACTERISTICS: * Tissue microarrays (TMA) samples from the Biopathology Core * Samples from patients diagnosed with brain tumors * Progenitor, or blast, cell origin PATIENT CHARACTERISTICS: * Not specified PRIOR CONCURRENT THERAPY: * Not specified

Design outcomes

Primary

Measure	Time frame
Correlation of NEIL3 expression and/or nuclear localization with tumor type or grade with respect to degree of differentiation	—

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026